Pivovarova, Olga, Fisher, Eva, Dudziak, Katarzyna, Ilkavets, Iryna, Dooley, Steven, Slominsky, Petr, Limborska, Svetlana, Weickert, Martin O., Spranger, Joachim, Fritsche, Andreas, Boeing, Heiner, Pfeiffer, Andreas F. H. and Rudovich, Natalia N.. (2011) A polymorphism within the connective tissue growth factor (CTGF) gene has no effect on non-invasive markers of beta-cell area and risk of type 2 diabetes. Disease Markers, Vol.31 (No.4). pp. 241-246. ISSN 0278-0240

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Abstract

Chromosomal locus 6q23 is strongly linked to type 2 diabetes (T2DM) and related features including insulin secretion in various ethnic populations. Connective tissue growth factor (CTGF) gene is an interesting T2DM candidate gene in this chromosome region. CTGF is a key mediator of progressive pancreatic fibrosis up-regulated in type 2 diabetes. In contrast, CTGF inactivation in mice compromises islet cell proliferation during embryogenesis. The aim of our study was to investigate an impact of CTGF genetic variation on pancreatic beta-cell function and T2DM pathogenesis. We studied the effect of a common CTGF polymorphism rs9493150 on the risk of the T2DM development in three independent German cohorts. Specifically, the association between CTGF polymorphism and non-invasive markers of beta-cell area derived from oral glucose tolerance test was studied in subjects without diabetes. Neither in the Metabolic Syndrome Berlin Potsdam (MESYBEPO) study (n = 1026) (OR = 0.637, CI (0.387-1.050); p = 0.077) nor in the European Prospective Investigation into Cancer and Nutrition-Potsdam (EPIC-Potsdam) (n = 3049) cohort (RR = 0.77 CI (0.49-1.20), p = 0.249 for the recessive homozygote in general model), a significant association with increased diabetes risk was observed. The risk allele of rs9493150 had also no effect on markers of beta-cell area in the combined analysis of the MESYBEPO and Tubingen Family Study (n = 1826). In conclusion, the polymorphism rs9493150 in the 5'-untranslated region of the CTGF gene has no association with T2DM risk and surrogate markers of beta-cell area.

Item Type:	Journal Article
Subjects:	Q Science > QH Natural history > QH426 Genetics R Medicine > RC Internal medicine
Divisions:	Faculty of Medicine > Warwick Medical School > Clinical Sciences Research Institute (CSRI) Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Genetic polymorphisms, Non-insulin-dependent diabetes, Pancreatic beta cells, Blood sugar, C-peptide, Genetic epidemiology, Connective tissues -- Growth
Journal or Publication Title:	Disease Markers
Publisher:	I O S Press
ISSN:	0278-0240
Date:	1 November 2011
Volume:	Vol.31
Number:	No.4
Page Range:	pp. 241-246
Identification Number:	10.3233/DMA-2011-0823
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Germany. Bundesministerium für Bildung und Forschung [Germany. Federal Ministry of Education and Research] (FMER), Deutscher Akademischer Austauschdienst [German Academic Exchange Service] (DAAD), Germany. Bundesministerium für Bildung und Wissenschaft [Germany. German Ministry of Education and Science] (BMBW), European Union (EU), German Cancer Aid (GCA), European Community (EC)
Grant number:	0313042C/NR (FMER), 01 EA 9401 (BMBW), SOC 95201408 05F02 (EU), 70-2488-Ha I (GCA), SOC 98200769 05F02 (EC)
URI:	http://wrap.warwick.ac.uk/id/eprint/40301

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