Towards a computational reconstruction of the electrodynamics of premature and full term human labour
Aslanidi, O., Atia, Jolene, Benson, Alan P., van den Berg, Hugo A., Blanks, Andrew M., Choi, C., Gilbert, S. H., Goryanin, Igor, Hayes-Gill, Barrie, Holden, Arun V., Li, P., Norman, Jane E., Shmygol, Anatoly, Simpson, N. A. B., Taggart, Michael J., Tong, Wing Chiu and Zhang, Henggui . (2011) Towards a computational reconstruction of the electrodynamics of premature and full term human labour. Progress in Biophysics and Molecular Biology, Vol.107 (No.1). pp. 183-192. ISSN 0079-6107Full text not available from this repository.
Official URL: http://dx.doi.org/10.1016/j.pbiomolbio.2011.07.004
We apply virtual tissue engineering to the full term human uterus with a view to reconstruction of the spatiotemporal patterns of electrical activity of the myometrium that control mechanical activity via intracellular calcium. The three-dimensional geometry of the gravid uterus has been reconstructed from segmented in vivo magnetic resonance imaging as well as ex vivo diffusion tensor magnetic resonance imaging to resolve fine scale tissue architecture. A late-pregnancy uterine smooth muscle cell model is constructed and bursting analysed using continuation algorithms. These cell models are incorporated into partial differential equation models for tissue synchronisation and propagation. The ultimate objective is to develop a quantitative and predictive understanding of the mechanisms that initiate and regulate labour.
|Item Type:||Journal Article|
|Subjects:||Q Science > QP Physiology
R Medicine > RG Gynecology and obstetrics
|Divisions:||Faculty of Medicine > Warwick Medical School > Translational & Systems Medicine > Reproductive Health
Faculty of Science > Centre for Systems Biology
Faculty of Medicine > Warwick Medical School
|Library of Congress Subject Headings (LCSH):||Electrohysterography, Uterus -- Contraction, Labor (Obstetrics) -- Mathematical models, Myometrium, Smooth muscle, Diffusion tensor imaging|
|Journal or Publication Title:||Progress in Biophysics and Molecular Biology|
|Official Date:||October 2011|
|Page Range:||pp. 183-192|
|Access rights to Published version:||Restricted or Subscription Access|
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