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Towards a computational reconstruction of the electrodynamics of premature and full term human labour
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Aslanidi, O., Atia, J., Benson, Alan P., Berg, Hugo van den, 1968-, Blanks, Andrew M., Choi, C., Gilbert, S. H., Goryanin, Igor, Hayes-Gill, Barrie, Holden, Arun V., 1947-, Li, P., Norman, Jane E., Shmygol, Anatoly, Simpson, N. A. B., Taggart, Michael John, Tong, Wing Chiu and Zhang, Henggui . (2011) Towards a computational reconstruction of the electrodynamics of premature and full term human labour. Progress in Biophysics and Molecular Biology, Vol.107 (No.1). pp. 183-192. ISSN 0079-6107
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Official URL: http://dx.doi.org/10.1016/j.pbiomolbio.2011.07.004
Abstract
We apply virtual tissue engineering to the full term human uterus with a view to reconstruction of the spatiotemporal patterns of electrical activity of the myometrium that control mechanical activity via intracellular calcium. The three-dimensional geometry of the gravid uterus has been reconstructed from segmented in vivo magnetic resonance imaging as well as ex vivo diffusion tensor magnetic resonance imaging to resolve fine scale tissue architecture. A late-pregnancy uterine smooth muscle cell model is constructed and bursting analysed using continuation algorithms. These cell models are incorporated into partial differential equation models for tissue synchronisation and propagation. The ultimate objective is to develop a quantitative and predictive understanding of the mechanisms that initiate and regulate labour.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QP Physiology R Medicine > RG Gynecology and obstetrics |
| Divisions: | Faculty of Medicine > Warwick Medical School > Reproductive Health Faculty of Science > Centre for Systems Biology Faculty of Medicine > Warwick Medical School |
| Library of Congress Subject Headings (LCSH): | Electrohysterography, Uterus -- Contraction, Labor (Obstetrics) -- Mathematical models, Myometrium, Smooth muscle, Diffusion tensor imaging |
| Journal or Publication Title: | Progress in Biophysics and Molecular Biology |
| Publisher: | Pergamon |
| ISSN: | 0079-6107 |
| Date: | October 2011 |
| Volume: | Vol.107 |
| Number: | No.1 |
| Page Range: | pp. 183-192 |
| Identification Number: | 10.1016/j.pbiomolbio.2011.07.004 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| URI: | http://wrap.warwick.ac.uk/id/eprint/40329 |
Data sourced from Thomson Reuters' Web of Knowledge
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