The Library
Towards a computational reconstruction of the electrodynamics of premature and full term human labour
Tools
Tools
Tools
Aslanidi, O., Atia, Jolene, Benson, Alan P., Berg, Hugo van den , Blanks, Andrew M., Choi, C., Gilbert, S. H., Goryanin, Igor, Hayes-Gill, Barrie, Holden, Arun V., Li, P., Norman, Jane E., Shmygol, Anatoly, Simpson, N. A. B., Taggart, Michael J., Tong, Wing Chiu and Zhang, Henggui (2011) Towards a computational reconstruction of the electrodynamics of premature and full term human labour. Progress in Biophysics and Molecular Biology, Vol.107 (No.1). pp. 183-192. doi:10.1016/j.pbiomolbio.2011.07.004 ISSN 0079-6107.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1016/j.pbiomolbio.2011.07.004
Abstract
We apply virtual tissue engineering to the full term human uterus with a view to reconstruction of the spatiotemporal patterns of electrical activity of the myometrium that control mechanical activity via intracellular calcium. The three-dimensional geometry of the gravid uterus has been reconstructed from segmented in vivo magnetic resonance imaging as well as ex vivo diffusion tensor magnetic resonance imaging to resolve fine scale tissue architecture. A late-pregnancy uterine smooth muscle cell model is constructed and bursting analysed using continuation algorithms. These cell models are incorporated into partial differential equation models for tissue synchronisation and propagation. The ultimate objective is to develop a quantitative and predictive understanding of the mechanisms that initiate and regulate labour.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QP Physiology R Medicine > RG Gynecology and obstetrics |
||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Reproductive Health ( - until July 2016) Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
||||
| Library of Congress Subject Headings (LCSH): | Electrohysterography, Uterus -- Contraction, Labor (Obstetrics) -- Mathematical models, Myometrium, Smooth muscle, Diffusion tensor imaging | ||||
| Journal or Publication Title: | Progress in Biophysics and Molecular Biology | ||||
| Publisher: | Pergamon | ||||
| ISSN: | 0079-6107 | ||||
| Official Date: | October 2011 | ||||
| Dates: |
|
||||
| Volume: | Vol.107 | ||||
| Number: | No.1 | ||||
| Page Range: | pp. 183-192 | ||||
| DOI: | 10.1016/j.pbiomolbio.2011.07.004 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
Data sourced from Thomson Reuters' Web of Knowledge
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
