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Insights into lasalocid a ring formation by chemical chain termination in vivo
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Tosin, Manuela, Smith, L. (Luke) and Leadlay, P. F. (2011) Insights into lasalocid a ring formation by chemical chain termination in vivo. Angewandte Chemie International Edition, Vol.50 (No.50). pp. 11930-11933. doi:10.1002/anie.201106323 ISSN 1433-7851.
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Official URL: http://dx.doi.org/10.1002/anie.201106323
Abstract
Caught in the act: Intermediates in the biosynthesis of lasalocid A are captured in vivo by malonyl carba(dethia)-N-acetyl cysteamine probes. These species constitute novel snapshots of the timing of ether and aromatic ring formation, thus providing valuable insights for the reconstruction and the engineering of polyether biosynthetic pathways.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QD Chemistry Q Science > QP Physiology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
| Library of Congress Subject Headings (LCSH): | Polyethers, Biosynthesis, Reaction mechanisms (Chemistry), Ring formation (Chemistry), Polyketides -- Therapeutic use, Enzymes | ||||
| Journal or Publication Title: | Angewandte Chemie International Edition | ||||
| Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA | ||||
| ISSN: | 1433-7851 | ||||
| Official Date: | 2011 | ||||
| Dates: |
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| Volume: | Vol.50 | ||||
| Number: | No.50 | ||||
| Page Range: | pp. 11930-11933 | ||||
| DOI: | 10.1002/anie.201106323 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Funder: | University of Cambridge Herchel Smith Fund, Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC) | ||||
| Grant number: | BB/I/002513/1 (BBSRC) |
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