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In vivo trapping of polyketide intermediates from an assembly line synthase using malonyl carba(dethia)-N-acetyl cysteamines
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Tosin, Manuela, Demydchuk, Yuliya, Parascandolo, James S., Blasco Per, Covadonga, Leeper, F. J. (Finian J.) and Leadlay, P. F. (2011) In vivo trapping of polyketide intermediates from an assembly line synthase using malonyl carba(dethia)-N-acetyl cysteamines. Chemical Communications, Vol.47 (No.12). pp. 3460-3462. doi:10.1039/c0cc05077f
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Official URL: http://dx.doi.org/10.1039/C0CC05077F
Abstract
Early-stage intermediates in the biosynthesis of erythromycin A by Saccharopolyspora erythraea were intercepted by malonyl carba(dethia)-N-acetyl cysteamines, generated in vivo from the hydrolysis of the corresponding methyl esters.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QD Chemistry Q Science > QP Physiology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
| Library of Congress Subject Headings (LCSH): | Polyketides -- Therapeutic use, Biosynthesis, Enzymes, Hydrolysis | ||||
| Journal or Publication Title: | Chemical Communications | ||||
| Publisher: | Royal Society of Chemistry | ||||
| ISSN: | 1359-7345 | ||||
| Official Date: | 2011 | ||||
| Dates: |
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| Volume: | Vol.47 | ||||
| Number: | No.12 | ||||
| Page Range: | pp. 3460-3462 | ||||
| DOI: | 10.1039/c0cc05077f | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Funder: | University of Cambridge Herchel Smith Fund |
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