The Library

In vivo trapping of polyketide intermediates from an assembly line synthase using malonyl carba(dethia)-N-acetyl cysteamines

Tools

Tosin, Manuela, Demydchuk, Yuliya, Parascandolo, James S., Blasco Per, Covadonga, Leeper, F. J. (Finian J.) and Leadlay, Peter F.. (2011) In vivo trapping of polyketide intermediates from an assembly line synthase using malonyl carba(dethia)-N-acetyl cysteamines. Chemical Communications, Vol.47 (No.12). pp. 3460-3462. ISSN 1359-7345

Full text not available from this repository.

Abstract

Early-stage intermediates in the biosynthesis of erythromycin A by Saccharopolyspora erythraea were intercepted by malonyl carba(dethia)-N-acetyl cysteamines, generated in vivo from the hydrolysis of the corresponding methyl esters.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Q Science > QP Physiology
Divisions: Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH): Polyketides -- Therapeutic use, Biosynthesis, Enzymes, Hydrolysis
Journal or Publication Title: Chemical Communications
Publisher: Royal Society of Chemistry
ISSN: 1359-7345
Official Date: 2011
Volume: Vol.47
Number: No.12
Page Range: pp. 3460-3462
Identification Number: 10.1039/c0cc05077f
Status: Peer Reviewed
Publication Status: Published
Funder: University of Cambridge Herchel Smith Fund
References:

1 K. J. Weissman, Methods Enzymol., 2009, 459, 3.
2 J. Kennedy, Nat. Prod. Rep., 2008, 25, 25.
3 S. Donadio, M. J. Staver, J. B. McAlpine, S. J. Swanson and
L. Katz, Science, 1991, 262, 675.
4 (a) J. Corte´ s, K. E. H. Wiesmann, G. A. Roberts, M. J. B. Brown,
J. Staunton and P. F. Leadlay, Science, 1995, 268, 1487;
(b) G. P. Horsman, Y. Chen, J. S. Thorson and B. Shen, Proc.
Natl. Acad. Sci. U. S. A., 2010, 107, 11331.
5 (a) B. Kusebauch, B. Busch, K. Scherlach, M. Roth and
C. Hertweck, Angew. Chem., Int. Ed., 2010, 49, 1460;
(b) J. Moldenhauer, D. C. G. Go¨ tz, C. R. Albert, S. K. Bishof,
K. Schneider, R. D. Su¨ ssmuth, M. Engeser, H. Gross,
G. Bringmann and J. Piel, Angew. Chem., Int. Ed., 2010, 49, 1465.
6 (a) J. M. Crawford, P. M. Thomas, J. R. Scheerer, A. L. Vagstad,
N. L. Kelleher and C. A. Townsend, Science, 2008, 320, 243;
(b) S. B. Bumpus, B. S. Evans, P. M. Thomas, I. Ntai and
N. L. Kelleher, Nat. Biotechnol., 2009, 27, 951.
7 M.Tosin,D. Spiteller and J.B. Spencer, ChemBioChem, 2009, 10, 1714.
8 M. Tosin, L. Betancor, E. Stephens, W. M. A. Li, J. B. Spencer and
P. F. Leadlay, ChemBioChem, 2010, 11, 539.
9 (a) S. M. Ma, J. W.-H. Li, J. W. Choi, H. Zhou, K. K. M. Lee,
V. A.Moorthie, X. Xie, J. T.Kealey, N. A. Da Silva, J. C. Vederas
and Y. Tang, Science, 2009, 326, 589; (b) Y. Sun, F. Hahn,
Y. Demydchuk, J. Chettle, M. Tosin, H. Osada and P. F. Leadlay,
Nat. Chem. Biol., 2010, 6, 99.
10 F. Lopez-Gallego and C. Schmidt-Dannert, Curr. Opin. Chem.
Biol., 2010, 14, 174.
11 S. J.Kwon,M. I.Kim,B.Ku, L.Coulombel, J.-H.Kim, J.H. Shawky,
R. L. Linhardt and J. S. Dordick, ChemBioChem, 2010, 11, 573.
12 J. Corte´ s, S. F. Haydock, G. A. Roberts, D. J. Bevitt and
P. F. Leadlay, Nature, 1990, 8, 176.
13 C. M. Kao, G. Luo, L. Katz, D. E. Cane and C. Khosla, J. Am.
Chem. Soc., 1996, 118, 9184.
14 J. D. Mortison, J. D. Kittendorf and D. H. Sherman, J. Am. Chem.
Soc., 2009, 131, 15784.
15 C. Corre and G. Challis, Nat. Prod. Rep., 2009, 26, 977.
16 (a) P. Caffrey, ChemBioChem, 2003, 4, 649; (b) A. Baerga-Ortiz,
B. Popovic, A. P. Siskos, H.M. O’Hare, D. Spiteller, M. G. Williams,
N. Campillo, J. B. Spencer andP.F.Leadlay, Chem.Biol., 2006, 13, 277.
17 (a) C. R. Valenzano, R. J. Lawson, A. Y. Chen, C. Khosla and
D. E. Cane, J. Am. Chem. Soc., 2009, 131, 1850; (b) L. Kellenberger,
I. S. Galloway, G. Sauter, G. Bo¨hm, U. Hanefeld, J. Corte´ s,
J. Staunton and P. F. Leadlay, ChemBioChem, 2008, 9, 2740.
URI: http://wrap.warwick.ac.uk/id/eprint/40340

Data sourced from Thomson Reuters' Web of Knowledge

Request changes or add full text files to a record

Actions (login required)

View Item View Item