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In vivo trapping of polyketide intermediates from an assembly line synthase using malonyl carba(dethia)-N-acetyl cysteamines

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Tosin, Manuela, Demydchuk, Yuliya, Parascandolo, James S., Blasco Per, Covadonga, Leeper, F. J. (Finian J.) and Leadlay, P. F.. (2011) In vivo trapping of polyketide intermediates from an assembly line synthase using malonyl carba(dethia)-N-acetyl cysteamines. Chemical Communications, Vol.47 (No.12). pp. 3460-3462. ISSN 1359-7345

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Official URL: http://dx.doi.org/10.1039/C0CC05077F

Abstract

Early-stage intermediates in the biosynthesis of erythromycin A by Saccharopolyspora erythraea were intercepted by malonyl carba(dethia)-N-acetyl cysteamines, generated in vivo from the hydrolysis of the corresponding methyl esters.

Item Type:

Journal Article

Subjects:

Q Science > QD Chemistry
Q Science > QP Physiology

Divisions:

Faculty of Science > Chemistry

Library of Congress Subject Headings (LCSH):

Polyketides -- Therapeutic use, Biosynthesis, Enzymes, Hydrolysis

Journal or Publication Title:

Chemical Communications

Publisher:

Royal Society of Chemistry

ISSN:

1359-7345

Official Date:

2011

Dates:

Date	Event
2011	Published

Volume:

Vol.47

Number:

No.12

Page Range:

pp. 3460-3462

Identification Number:

10.1039/c0cc05077f

Status:

Peer Reviewed

Publication Status:

Published

Funder:

University of Cambridge Herchel Smith Fund

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