Tosin, Manuela, Demydchuk, Yuliya, Parascandolo, James S., Blasco Per, Covadonga, Leeper, F. J. (Finian J.) and Leadlay, Peter F.. (2011) In vivo trapping of polyketide intermediates from an assembly line synthase using malonyl carba(dethia)-N-acetyl cysteamines. Chemical Communications, Vol.47 (No.12). pp. 3460-3462. ISSN 1359-7345

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Abstract

Early-stage intermediates in the biosynthesis of erythromycin A by Saccharopolyspora erythraea were intercepted by malonyl carba(dethia)-N-acetyl cysteamines, generated in vivo from the hydrolysis of the corresponding methyl esters.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry Q Science > QP Physiology
Divisions:	Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH):	Polyketides -- Therapeutic use, Biosynthesis, Enzymes, Hydrolysis
Journal or Publication Title:	Chemical Communications
Publisher:	Royal Society of Chemistry
ISSN:	1359-7345
Date:	2011
Volume:	Vol.47
Number:	No.12
Page Range:	pp. 3460-3462
Identification Number:	10.1039/c0cc05077f
Status:	Peer Reviewed
Publication Status:	Published
Funder:	University of Cambridge Herchel Smith Fund
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URI:	http://wrap.warwick.ac.uk/id/eprint/40340

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