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In vivo trapping of polyketide intermediates from an assembly line synthase using malonyl carba(dethia)-N-acetyl cysteamines
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Tosin, Manuela, Demydchuk, Yuliya, Parascandolo, James S., Blasco Per, Covadonga, Leeper, F. J. (Finian J.) and Leadlay, Peter F.. (2011) In vivo trapping of polyketide intermediates from an assembly line synthase using malonyl carba(dethia)-N-acetyl cysteamines. Chemical Communications, Vol.47 (No.12). pp. 3460-3462. ISSN 1359-7345
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Official URL: http://dx.doi.org/10.1039/C0CC05077F
Abstract
Early-stage intermediates in the biosynthesis of erythromycin A by Saccharopolyspora erythraea were intercepted by malonyl carba(dethia)-N-acetyl cysteamines, generated in vivo from the hydrolysis of the corresponding methyl esters.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QD Chemistry Q Science > QP Physiology |
| Divisions: | Faculty of Science > Chemistry |
| Library of Congress Subject Headings (LCSH): | Polyketides -- Therapeutic use, Biosynthesis, Enzymes, Hydrolysis |
| Journal or Publication Title: | Chemical Communications |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 1359-7345 |
| Date: | 2011 |
| Volume: | Vol.47 |
| Number: | No.12 |
| Page Range: | pp. 3460-3462 |
| Identification Number: | 10.1039/c0cc05077f |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Funder: | University of Cambridge Herchel Smith Fund |
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| URI: | http://wrap.warwick.ac.uk/id/eprint/40340 |
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