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The anticancer drug cisplatin can cross-link the interdomain zinc site on human albumin
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Hu, Wenbing, Luo, Qun, Wu, Kui, Li, Xianchan, Wang, Fuyi, Chen, Yi, Ma, Xiaoyan, Wang, Jianping, Liu, Jianan, Xiong, Shaoxiang and Sadler, P. J. (2011) The anticancer drug cisplatin can cross-link the interdomain zinc site on human albumin. Chemical Communications, Vol.47 (No.21). pp. 6006-6008. doi:10.1039/c1cc11627d ISSN 1359-7345.
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WRAP_Sadler_465_Pt-rHA ChemCommun ver4.pdf - Accepted Version Download (485Kb) | Preview |
Official URL: http://dx.doi.org/10.1039/C1CC11627D
Abstract
Cisplatin, cis-[Pt(Cl2(NH3)2], can crosslink residues His67 of domain I and His247 of domain II in human albumin, occupying the major binding site for the essential metal zinc on the protein.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry Q Science > QP Physiology R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Library of Congress Subject Headings (LCSH): | Cisplatin, Antineoplastic agents, Albumins | ||||
Journal or Publication Title: | Chemical Communications | ||||
Publisher: | Royal Society of Chemistry | ||||
ISSN: | 1359-7345 | ||||
Official Date: | 7 June 2011 | ||||
Dates: |
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Volume: | Vol.47 | ||||
Number: | No.21 | ||||
Page Range: | pp. 6006-6008 | ||||
DOI: | 10.1039/c1cc11627d | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Date of first compliant deposit: | 18 December 2015 | ||||
Date of first compliant Open Access: | 18 December 2015 | ||||
Funder: | Guo jia zi ran ke xue ji jin wei yuan hui (China) [National Natural Science Foundation of China] (NSFC), Zhongguo ke xue yuan [Chinese Academy of Sciences] (CAS), China. Guo jia ke xue ji shu bu [Ministry of Science and Technology] | ||||
Grant number: | 90713020 (NSFC), 20975103 (NSFC), 21020102039 (NSFC) |
Data sourced from Thomson Reuters' Web of Knowledge
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