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The anticancer drug cisplatin can cross-link the interdomain zinc site on human albumin

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Hu, Wenbing, Luo, Qun, Wu, Kui, Li, Xianchan, Wang, Fuyi, Chen, Yi, Ma, Xiaoyan, Wang, Jianping, Liu, Jianan, Xiong, Shaoxiang and Sadler, P. J. (2011) The anticancer drug cisplatin can cross-link the interdomain zinc site on human albumin. Chemical Communications, Vol.47 (No.21). pp. 6006-6008. doi:10.1039/c1cc11627d

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WRAP_Sadler_465_Pt-rHA ChemCommun ver4.pdf - Accepted Version

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Official URL: http://dx.doi.org/10.1039/C1CC11627D

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Abstract

Cisplatin, cis-[Pt(Cl2(NH3)2], can crosslink residues His67 of domain I and His247 of domain II in human albumin, occupying the major binding site for the essential metal zinc on the protein.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Q Science > QP Physiology
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH): Cisplatin, Antineoplastic agents, Albumins
Journal or Publication Title: Chemical Communications
Publisher: Royal Society of Chemistry
ISSN: 1359-7345
Official Date: 7 June 2011
Dates:
DateEvent
7 June 2011Published
Volume: Vol.47
Number: No.21
Page Range: pp. 6006-6008
DOI: 10.1039/c1cc11627d
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: Guo jia zi ran ke xue ji jin wei yuan hui (China) [National Natural Science Foundation of China] (NSFC), Zhongguo ke xue yuan [Chinese Academy of Sciences] (CAS), China. Guo jia ke xue ji shu bu [Ministry of Science and Technology]
Grant number: 90713020 (NSFC), 20975103 (NSFC), 21020102039 (NSFC)

Data sourced from Thomson Reuters' Web of Knowledge

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