Hopewell, Jonathan P., Martins, José E. D., Johnson, Tarn C., Godfrey, Jamie and Wills, Martin (2012) Developing asymmetric iron and ruthenium-based cyclone complexes : complex factors influence the asymmetric induction in the transfer hydrogenation of ketones. Organic & Biomolecular Chemistry, Vol.10 (No.1). pp. 134-145. doi:10.1039/c1ob06010d

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Abstract

The preparation of a range of asymmetric iron and ruthenium-cyclone complexes, and their application to the asymmetric reduction of a ketone, are described. The enantioselectivity of ketone reduction is influenced by a single chiral centre in the catalyst, as well as by the planar chirality in the catalyst. This represents the first example of asymmetric ketone reduction using an iron cyclone catalyst.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry
Divisions:	Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH):	Asymmetric synthesis, Ketones, Iron, Ruthenium
Journal or Publication Title:	Organic & Biomolecular Chemistry
Publisher:	Royal Society of Chemistry
ISSN:	1477-0520
Official Date:	2012
Dates:	Date Event 2012 Published
Date of first compliant deposit:	18 December 2015
Volume:	Vol.10
Number:	No.1
Page Range:	pp. 134-145
DOI:	10.1039/c1ob06010d
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Engineering and Physical Sciences Research Council (EPSRC), University of Warwick
Grant number:	EP/F019424 (EPSRC), EP/G01244X/1 (EPSRC)

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