Insights into the acid-base properties of PtIV-diazidodiam(m)inedihyroxido complexes from multinuclear NMR spectroscopy
Ronconi, Luca, Pizarro, Ana M., McQuitty, Ruth J. and Sadler, P. J.. (2011) Insights into the acid-base properties of PtIV-diazidodiam(m)inedihyroxido complexes from multinuclear NMR spectroscopy. Chemistry - A European Journal, Volume 17 (Number 43). pp. 12051-12058. ISSN 0947-6539
WRAP_Pizarro_Insights_acid_base_12051_ftp.pdf - Published Version
Available under License Creative Commons Attribution.
Download (591Kb) | Preview
Official URL: http://dx.doi.org/10.1002/chem.201002792
Platinum(IV) am(m)ine complexes are of interest as potential anticancer pro-drugs, but there are few reports of their acid–base properties. We have studied the acid–base properties of three photoactivatable anticancer platinum(IV)-diazidodiam(m)ine complexes (cis,trans,cis-[PtIV(N3)2(OH)2(NH3)2], trans,trans,trans-[PtIV(N3)2(OH)2(NH3)2], and cis,trans-[PtIV(N3)2(OH)2(en)]) using multinuclear NMR methods and potentiometry. In particular, the combination of both direct and indirect techniques for the detection of 15N signals has allowed changes of the chemical shifts to be followed over the pH range 1–11; complementary 14N NMR studies have been also carried out. A distinct pKa value of approximately 3.4 was determined for all the investigated complexes, involving protonation/deprotonation reactions of one of the axial hydroxido groups, whereas a second pH-dependent change for the three complexes at approximately pH 7.5 appears not to be associated with a loss of an am(m)ine or hydroxido proton from the complex. Our findings are discussed in comparison with the limited data available in the literature on related complexes.
|Item Type:||Journal Article|
|Subjects:||Q Science > QC Physics
Q Science > QD Chemistry
|Divisions:||Faculty of Science > Chemistry|
|Library of Congress Subject Headings (LCSH):||Acid-base chemistry, Bioinorganic chemistry, Antineoplastic agents, Nuclear magnetic resonance spectroscopy, Platinum compounds -- Therapeutic use, Potentiometry, Electrochemical analysis, Cancer -- Treatment|
|Journal or Publication Title:||Chemistry - A European Journal|
|Publisher:||Wiley - V C H Verlag GmbH & Co. KGaA|
|Official Date:||17 October 2011|
|Page Range:||pp. 12051-12058|
|Access rights to Published version:||Open Access|
|Funder:||Marie Curie Intra-European Fellowship (IEF), Engineering and Physical Sciences Research Council (EPSRC), European Research Council (ERC), European Regional Development Fund (ERDF), Advantage West Midlands (AWM), Science City Research Alliance|
|Grant number:||EP/G006792/1 (EPSRC) ; 247450 (ERC)|
 L. Kelland, Nat. Rev. Cancer 2007, 7, 573 – 584.
Actions (login required)