Antibody-mediated resistance against plant pathogens
Safarnejad, Mohammad Reza, Jouzani, Gholamreza Salehi, Tabatabaie, Meisam, Twyman, Richard M. and Schillberg, Stefan. (2011) Antibody-mediated resistance against plant pathogens. Biotechnology Advances, Volume 29 (Number 6). pp. 961-971. ISSN 0734-9750Full text not available from this repository.
Official URL: http://dx.doi.org/10.1016/j.biotechadv.2011.08.011
Plant diseases have a significant impact on the yield and quality of crops. Many strategies have been developed to combat plant diseases, including the transfer of resistance genes to crops by conventional breeding. However, resistance genes can only be introgressed from sexually-compatible species, so breeders need alternative measures to introduce resistance traits from more distant sources. In this context, genetic engineering provides an opportunity to exploit diverse and novel forms of resistance, e.g. the use of recombinant antibodies targeting plant pathogens. Native antibodies, as a part of the vertebrate adaptive immune system, can bind to foreign antigens and eliminate them from the body. The ectopic expression of antibodies in plants can also interfere with pathogen activity to confer disease resistance. With sufficient knowledge of the pathogen life cycle, it is possible to counter any disease by designing expression constructs so that pathogen-specific antibodies accumulate at high levels in appropriate sub-cellular compartments. Although first developed to tackle plant viruses and still used predominantly for this purpose, antibodies have been targeted against a diverse range of pathogens as well as proteins involved in plant-pathogen interactions. Here we comprehensively review the development and implementation of antibody-mediated disease resistance in plants.
|Item Type:||Journal Article|
|Subjects:||Q Science > QH Natural history > QH426 Genetics
Q Science > QK Botany
S Agriculture > SB Plant culture
|Divisions:||Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010)|
|Library of Congress Subject Headings (LCSH):||Genetic engineering, Bacteriophages, Transgenic plants, Recombinant antibodies, Plants -- Disease and pest resistance, Mosaic viruses|
|Journal or Publication Title:||Biotechnology Advances|
|Page Range:||pp. 961-971|
|Access rights to Published version:||Restricted or Subscription Access|
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