Selenium status and blood lipids : the cardiovascular risk in young Finns study
Stranges, Saverio, Tabák, A. G., Guallar, Eliseo, Rayman, Margaret, Akbaraly, T. N, Laclaustra, Martin, Alfthan, G., Mussalo-Rauhamaa, H., Viikari, J. S. A., Raitakari, O. T. and Kivimäki, Mika. (2011) Selenium status and blood lipids : the cardiovascular risk in young Finns study. Journal of Internal Medicine, Volume 270 (Number 5). pp. 469-477. ISSN 0954-6820Full text not available from this repository.
Official URL: http://dx.doi.org/10.1111/j.1365-2796.2011.02398.x
Background. Concern has been recently raised about possible adverse cardio-metabolic effects of high selenium status, such as increased risks of diabetes and hyperlipidaemia. However, most of the evidence comes from selenium-replete populations such as that of the United States.
Objectives. To examine cross-sectional and longitudinal associations of serum selenium with cardiovascular risk factors in Finland where selenium levels were amongst the lowest in the world until the early 1980s before the implementation of a nationwide selenium fertilization programme.
Methods. Serum selenium was measured in 1235 young Finns aged 3-18 years at baseline in 1980 (prefertilization) and in a subgroup (N = 262) at the 6-year follow-up (1986, postfertilization). During the 27-year follow-up, serumlipids, blood pressure, body mass index and smoking were assessed five times (1980,1983,1986,2001 and 2007).
Results. Mean (+/-SD) serum selenium concentrations were 74.3 +/- 14.0 ng mL(-1) in 1980 and 106.6 +/- 12.5 ng mL(-1) in 1986 (average increase 32.3 ng mL(-1); 95% CI: 30.3 to 34.3, P < 0.0001). In univariate and multivariable cross-sectional models in 1980 and 1986, increased serum selenium levels were consistently associated with increased total, HDL and Low-density lipoprotein (LDL) cholesterol. However, the average longitudinal changes in lipids were -0.20 mmol L(-1) (95% CI: -0.30 to -0.10, P < 0.0001) for total cholesterol, 0.06 mmol L(-1) (95% CI: 0.03 to 0.10, P < 0.0001) for HDL cholesterol, and) 0.23 mmol L(-1) (95% CI: -0.31 to -0.14, P < 0.0001) for LDL cholesterol. Selenium measured in 1986 was not associated with lipids assessed in 2001 and 2007.
Conclusions. Cross-sectional findings from the Young Finns study corroborate positive associations of selenium status with serum lipids. However, longitudinal evidence does not support the causality of this link.
|Item Type:||Journal Article|
|Subjects:||Q Science > QP Physiology
R Medicine > RC Internal medicine
|Divisions:||Faculty of Medicine > Warwick Medical School > Health Sciences
Faculty of Medicine > Warwick Medical School
|Library of Congress Subject Headings (LCSH):||Selenium, Blood lipids, Young adults -- Health and hygiene -- Finland, Cardiovascular system -- Diseases -- Risk factors -- Finland, Cardiovascular system -- Diseases -- Longitudinal studies|
|Journal or Publication Title:||Journal of Internal Medicine|
|Publisher:||Wiley-Blackwell Publishing Ltd.|
|Official Date:||November 2011|
|Page Range:||pp. 469-477|
|Access rights to Published version:||Restricted or Subscription Access|
|Funder:||Suomen Akatemia [Academy of Finland] (SF), Kansaneläkelaitos (Finland) [Social Insurance Institution, Finland], Turun Yliopistosaatio [Turku University Foundation] (TY), Kuopio University Hospital, Emil Aaltonen Foundation, Juho Vainio Foundation, Finnish Foundation of Cardiovascular Research, Suomen Kulttuurirahasto [Finnish Cultural Foundation] (SK), National Heart, Lung, and Blood Institute (NHLBI), National Institute on Aging (NIA), British United Provident Association (BUPA), Turku University Hospital, Tampere University Hospital|
|Grant number:||77841 (SF), 117832 (SF), 201888 (SF), 121584 (SF), R01 HL036310-20A2 (NHLBI), R01AG034454 (NIA),|
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