Antimicrobial activity of ruthenium-based intercalators
Bolhuis, Albert, Hand, Lorna, Marshall, Julia E., Richards, Adair D., Rodger, Alison and Aldrich-Wright, Janice. (2011) Antimicrobial activity of ruthenium-based intercalators. European Journal of Pharmaceutical Sciences, Vol.42 (No.4). pp. 313-317. ISSN 0928-0987Full text not available from this repository.
Official URL: http://dx.doi.org/10.1016/j.ejps.2010.12.004
Multidrug resistance of bacterial pathogens is a major problem and there is a clear need for the development of new types of antibiotics. Here we investigated the antimicrobial activity of ruthenium(II) based DNA-intercalating complexes. These complexes were found to have no activity in vitro against the Gram-negative bacterium Escherichia coil, but the complexes were clearly active against the Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus. In vivo activity has also been demonstrated for one of the compounds using a simple infection model, the nematode Caenorhabditis elegans. Importantly, this also showed that the compound tested was not toxic to the nematodes. (C) 2010 Elsevier B.V. All rights reserved.
|Item Type:||Journal Article|
|Subjects:||Q Science > QD Chemistry
Q Science > QR Microbiology
R Medicine > RM Therapeutics. Pharmacology
|Divisions:||Faculty of Science > Chemistry|
|Library of Congress Subject Headings (LCSH):||Ruthenium -- Therapeutic use, Anti-infective agents, Staphylococcus aureus, Caenorhabditis elegans, Methicillin resistance|
|Journal or Publication Title:||European Journal of Pharmaceutical Sciences|
|Date:||18 March 2011|
|Page Range:||pp. 313-317|
|Access rights to Published version:||Restricted or Subscription Access|
|Funder:||Engineering and Physical Sciences Research Council (EPSRC), University of Western Sydney, University of Warwick. Molecular Organisation and Assembly in Cells|
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