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Antimicrobial activity of ruthenium-based intercalators
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Bolhuis, Albert, Hand, Lorna, Marshall, Julia E., Richards, Adair D., Rodger, Alison and Aldrich-Wright, Janice. (2011) Antimicrobial activity of ruthenium-based intercalators. European Journal of Pharmaceutical Sciences, Vol.42 (No.4). pp. 313-317. ISSN 0928-0987
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Official URL: http://dx.doi.org/10.1016/j.ejps.2010.12.004
Abstract
Multidrug resistance of bacterial pathogens is a major problem and there is a clear need for the development of new types of antibiotics. Here we investigated the antimicrobial activity of ruthenium(II) based DNA-intercalating complexes. These complexes were found to have no activity in vitro against the Gram-negative bacterium Escherichia coil, but the complexes were clearly active against the Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus. In vivo activity has also been demonstrated for one of the compounds using a simple infection model, the nematode Caenorhabditis elegans. Importantly, this also showed that the compound tested was not toxic to the nematodes. (C) 2010 Elsevier B.V. All rights reserved.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QD Chemistry Q Science > QR Microbiology R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Faculty of Science > Chemistry |
| Library of Congress Subject Headings (LCSH): | Ruthenium -- Therapeutic use, Anti-infective agents, Staphylococcus aureus, Caenorhabditis elegans, Methicillin resistance |
| Journal or Publication Title: | European Journal of Pharmaceutical Sciences |
| Publisher: | Elsevier BV |
| ISSN: | 0928-0987 |
| Date: | 18 March 2011 |
| Volume: | Vol.42 |
| Number: | No.4 |
| Page Range: | pp. 313-317 |
| Identification Number: | 10.1016/j.ejps.2010.12.004 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| Funder: | Engineering and Physical Sciences Research Council (EPSRC), University of Western Sydney, University of Warwick. Molecular Organisation and Assembly in Cells |
| URI: | http://wrap.warwick.ac.uk/id/eprint/40474 |
Data sourced from Thomson Reuters' Web of Knowledge
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