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Antimicrobial activity of ruthenium-based intercalators

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Bolhuis, Albert, Hand, Lorna, Marshall, Julia E., Richards, Adair D., Rodger, Alison and Aldrich-Wright, Janice (2011) Antimicrobial activity of ruthenium-based intercalators. European Journal of Pharmaceutical Sciences, Vol.42 (No.4). pp. 313-317. doi:10.1016/j.ejps.2010.12.004

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Official URL: http://dx.doi.org/10.1016/j.ejps.2010.12.004

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Abstract

Multidrug resistance of bacterial pathogens is a major problem and there is a clear need for the development of new types of antibiotics. Here we investigated the antimicrobial activity of ruthenium(II) based DNA-intercalating complexes. These complexes were found to have no activity in vitro against the Gram-negative bacterium Escherichia coil, but the complexes were clearly active against the Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus. In vivo activity has also been demonstrated for one of the compounds using a simple infection model, the nematode Caenorhabditis elegans. Importantly, this also showed that the compound tested was not toxic to the nematodes. (C) 2010 Elsevier B.V. All rights reserved.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Q Science > QR Microbiology
R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH): Ruthenium -- Therapeutic use, Anti-infective agents, Staphylococcus aureus, Caenorhabditis elegans, Methicillin resistance
Journal or Publication Title: European Journal of Pharmaceutical Sciences
Publisher: Elsevier BV
ISSN: 0928-0987
Official Date: 18 March 2011
Dates:
DateEvent
18 March 2011Published
Volume: Vol.42
Number: No.4
Page Range: pp. 313-317
DOI: 10.1016/j.ejps.2010.12.004
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: Engineering and Physical Sciences Research Council (EPSRC), University of Western Sydney, University of Warwick. Molecular Organisation and Assembly in Cells

Data sourced from Thomson Reuters' Web of Knowledge

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