Gibson, Matthew I., Barker, Carl A., Spain, Sebastian G., Albertin, Luca and Cameron, Neil R. (2009) Inhibition of ice crystal growth by synthetic glycopolymers : implications for the rational design of antifreeze glycoprotein mimics. Biomacromolecules, Vol.10 (No.2). pp. 328-333. doi:10.1021/bm801069x ISSN 1525-7797.

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Abstract

A series of structurally diverse polymers, containing either peptide or vinyl-derived backbones, was tested for ice recrystallization inhibition activity, which is commonly associated with antifreeze (glyco)proteins. It was revealed that only polymers bearing hydroxyl groups in the side chain could inhibit ice growth. Furthermore, well-defined glycopolymers were shown to have a small but significant recrystallization inhibition effect, showing that it may be possible to design antifreeze glycoprotein mimics based upon polymers derived from vinyl monomers.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry
Divisions:	Faculty of Science, Engineering and Medicine > Science > Chemistry
Library of Congress Subject Headings (LCSH):	Ice crystals -- Growth, Glycoproteins, Polymers, Antifreeze proteins, Polymerization, Hydroxyl group
Journal or Publication Title:	Biomacromolecules
Publisher:	American Chemical Society
ISSN:	1525-7797
Official Date:	February 2009
Dates:	Date Event February 2009 Published
Volume:	Vol.10
Number:	No.2
Page Range:	pp. 328-333
DOI:	10.1021/bm801069x
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Engineering and Physical Sciences Research Council (EPSRC), Imperial Chemical Industries, ltd. (ICI)

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