Lewandowski, Józef R., Sass, Hans Jürgen, Grzesiek, Stephan, Blackledge, Martin and Emsley, Lyndon. (2011) Site-specific measurement of slow motions in proteins. Journal of the American Chemical Society, Vol.133 (No.42). pp. 16762-16765. ISSN 0002-7863

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Abstract

We demonstrate that a quantitative measure of slow molecular motions in solid proteins can be accessed by measuring site-specific 15N rotating-frame relaxation rates at high magic-angle-spinning frequencies.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry
Divisions:	Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH):	Proteins, Molecular dynamics, Nuclear magnetic resonance spectroscopy
Journal or Publication Title:	Journal of the American Chemical Society
Publisher:	American Chemical Society
ISSN:	0002-7863
Date:	26 October 2011
Volume:	Vol.133
Number:	No.42
Page Range:	pp. 16762-16765
Identification Number:	10.1021/ja206815h
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	France. Agence nationale de la recherche (ANR), Seventh Framework Programme (European Commission) (FP7), Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung [Swiss National Science Foundation] (SNSF), European Union (EU)
Grant number:	BioNMR 261863 (FP7), 31-132857 (SNSF), PIRG03-GA-2008-231026 (EU)
References:	(1) Salmon, L.; Bouvignies, G.; Markwick, P.; Lakomek, N.; Showalter, S.; Li, D. W.; Walter, K.; Griesinger, C.; Bruschweiler, R.; Blackledge, M. Angew. Chem., Int. Ed. 2009, 48, 4154. (2) Giraud, N.; Bockmann, A.; Lesage, A.; Penin, F.; Blackledge, M.; Emsley, L. J. Am. Chem. Soc. 2004, 126, 11422. (3) Lewandowski, J. R.; Sein, J.; Sass, H. J.; Grzesiek, S.; Blackledge, M.; Emsley, L. J. Am. Chem. Soc. 2010, 132, 8252. (4) Vanderhart, D. L.; Garroway, A. N. J. Chem. Phys. 1979, 71, 2773. (5) Akasaka, K.; Ganapathy, S.; Mcdowell, C. A.; Naito, A. J. Chem. Phys. 1983, 78, 3567. (6) Chevelkov, V.; Diehl, A.; Reif, B. Magn. Reson. Chem. 2007, 45, S156. (7) Chevelkov, V.; Fink, U.; Reif, B. J. Biomol. NMR 2009, 45, 197. (8) Cavanagh, J.; Fairbrother, W. J.; Palmer, A. G., III; Skelton, N. J.; Rance, M. Protein NMR Spectroscopy: Principles and Practice, 2nd ed.; Academic Press: San Diego, CA, 2006. (9) Krushelnitsky, A.; Zinkevich, T.; Reichert, D.; Chevelkov, V.; Reif, B. J. Am. Chem. Soc. 2010, 132, 11850. (10) For the bulk measurement, the integral over the backbone amide resonances was monitored as a function of relaxation delay. (11) Lesage,A.;Bardet,M.;Emsley,L. J.Am.Chem. Soc. 1999, 121, 10987. (12) Peng, J.W.; Thanabal, V.; Wagner, G. J. Magn. Reson. 1991, 94, 82. (13) Oas, T. G.; Griffin,R.G.;Levitt, M. H. J. Chem. Phys. 1988, 89, 692. (14) Levitt, M. H.; Oas, T. G.; Griffin, R. G. Isr. J. Chem. 1988, 28, 271. (15) Nielsen, N. C.; Bildsoe, H.; Jakobsen, H. J.; Levitt, M. H. J. Chem. Phys. 1994, 101, 1805. (16) Lienin, S. F. Eidgenossische Technische Hochschule, 1998. (17) Giraud, N.; Blackledge, M.; Goldman, M.; Bockmann, A.; Lesage, A.; Penin, F.; Emsley, L. J. Am. Chem. Soc. 2005, 127, 18190. (18) Bruschweiler, R.;Wright, P. E. J. Am. Chem. Soc. 1994, 116, 8426. (19) Lewandowski, J. R.; Sein, J.; Blackledge, M.; Emsley, L. J. Am. Chem. Soc. 2010, 132, 1246. (20) Lipari, G.; Szabo, A. J. Am. Chem. Soc. 1982, 104, 4546. (21) Bremi, T.; Bruschweiler, R. J. Am. Chem. Soc. 1997, 119, 6672. (22) Wigley, D. B.; Derrick, J. P.; Shaw,W. V. FEBS Lett. 1990, 277, 267. (23) Idiyatullin, D.; Daragan, V. A.; Mayo, K. H. J. Phys. Chem. B 2003, 107, 2602. (24) Derrick, J. P.; Wigley, D. B. J. Mol. Biol. 1994, 243, 906.
URI:	http://wrap.warwick.ac.uk/id/eprint/40588

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