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Artifacts in fourier transform mass spectrometry
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Mathur, Raman and O'Connor, Peter B. (2009) Artifacts in fourier transform mass spectrometry. Rapid Communications in Mass Spectrometry, Vol.23 (No.4). pp. 523-529. doi:10.1002/rcm.3904 ISSN 09514198.
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Official URL: http://dx.doi.org/10.1002/rcm.3904
Abstract
Recent work on a new, higher sensitivity preamplifier design for Fourier transform ion cyclotron resonance mass spectrometry (FTICRMS) revealed a number of artifact peaks (spectral features) which do not contain useful chemical information. In order to determine the cause of these artifacts and eliminate them, these severely distorted spectra were compared with similarly distorted signal models. The source of several common signal processing artifacts was thereby determined and correlated to radio-frequency interference (RFI) noise and saturation of the amplifier and/or the digitizer. Under such conditions, the fast Fourier transform (FFT) generates spectral artifact peaks corresponding to harmonics and mixing frequencies of the real signal peaks and RFI frequencies. While this study was done using FTICRMS data, it is important to stress that these artifacts are inherent to the digitization and FFT process and thus are relevant to any FT-based MS instrument, including the orbitrap and FT ion trap. Copyright © 2009 John Wiley & Sons, Ltd.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QC Physics Q Science > QD Chemistry |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
| Library of Congress Subject Headings (LCSH): | Fourier transform spectroscopy, Mass spectrometry, Ion cyclotron resonance spectrometry, Space charge | ||||
| Journal or Publication Title: | Rapid Communications in Mass Spectrometry | ||||
| Publisher: | John Wiley & Sons Ltd. | ||||
| ISSN: | 09514198 | ||||
| Official Date: | February 2009 | ||||
| Dates: |
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| Volume: | Vol.23 | ||||
| Number: | No.4 | ||||
| Number of Pages: | 7 | ||||
| Page Range: | pp. 523-529 | ||||
| DOI: | 10.1002/rcm.3904 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | National Institute of General Medical Sciences (U.S.) (NIGMS), National Institutes of Health (U.S.) (NIH), National Heart, Lung, and Blood Institute (NHLBI), National Center for Research Resources (U.S.) (NCRR), MDS Sciex | ||||
| Grant number: | P41PR10888 (NIH/NCRR), N01IIV28178 (NIH/NHLBI), R01GM78293 (NIH/NIGMS) |
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