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Modeling binding affinity at peptide-surface interfaces : the role of mutations
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Walsh, Tiffany R., Notman, Rebecca, Skelton, A. A., Liang, Taining and Tomasio, Susana de Miranda (2009) Modeling binding affinity at peptide-surface interfaces : the role of mutations. In: The 237th ACS National Meeting March 22-26, 2009, Salt Lake City, UT, 22-26 Mar 2009. Published in: American Chemical Society. Abstracts of Papers (at the National Meeting), Vol.237 3-NANO.
Full text not available from this repository.Abstract
While many different peptide sequences have now been experimentally identified to have strong affinity for a huge range of materials, the question of why a given sequence binds so well while another does not remains to be properly answered. Use of molecular simluations is one of many complementary techniques that enables us to address these questions. In this contribution, a summary of our molecular simulation work in this area is presented. We have identified the crucial role of intra-peptide interactions in peptide-inorganic binding for both titania (below) and silica binders. We have also made a detailed investigation of the importance of tryptophan in nanotube-binding peptides via point mutations, and advance a hypothesis based on interfacial shape, explaining why aromatic residues might not dominate in graphite-binding peptides.
| Item Type: | Conference Item (Paper) |
|---|---|
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
| Divisions: | Faculty of Science > Chemistry |
| Library of Congress Subject Headings (LCSH): | Peptides, Interfaces (Physical sciences), Molecules -- Models -- Computer simulation, Mutation (Biology) |
| Journal or Publication Title: | American Chemical Society. Abstracts of Papers (at the National Meeting) |
| Publisher: | American Chemical Society |
| ISSN: | 0065-7727 |
| Date: | 22 March 2009 |
| Volume: | Vol.237 |
| Page Range: | 3-NANO |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| Conference Paper Type: | Paper |
| Title of Event: | The 237th ACS National Meeting March 22-26, 2009 |
| Type of Event: | Conference |
| Location of Event: | Salt Lake City, UT |
| Date(s) of Event: | 22-26 Mar 2009 |
| URI: | http://wrap.warwick.ac.uk/id/eprint/40612 |
Data sourced from Thomson Reuters' Web of Knowledge
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