Molecular basis for dimethylsulfoxide (DMSO) action on lipid membranes
Notman, Rebecca, Noro, Massimo, O'Malley, B. and Anwar, Jamshed. (2006) Molecular basis for dimethylsulfoxide (DMSO) action on lipid membranes. Journal of the American Chemical Society, Vol.128 (No.43). pp. 13982-13983. ISSN 0002-7863Full text not available from this repository.
Official URL: http://dx.doi.org/10.1021/ja063363t
Dimethylsulfoxide (DMSO) is an aprotic solvent that has the ability to induce cell fusion and cell differentiation and enhance the permeability of lipid membranes. It is also an effective cryoprotectant. Insights into how this molecule modulates membrane structure and function would be invaluable toward regulating the above processes and for developing chemical means for enhancing or hindering the absorption of biologically active molecules, in particular into or via the skin. We show here by means of molecular simulations that DMSO can induce water pores in dipalmitoyl-phosphatidylcholine bilayers and propose this to be a possible pathway for the enhancement of penetration of actives through lipid membranes. DMSO also causes the membrane to become floppier, which would enhance permeability, facilitate membrane fusion, and enable the cell membrane to accommodate osmotic and mechanical stresses during cryopreservation.
|Item Type:||Journal Article|
|Subjects:||Q Science > QD Chemistry
Q Science > QP Physiology
|Divisions:||Faculty of Science > Chemistry|
|Library of Congress Subject Headings (LCSH):||Dimethyl sulfoxide, Lipid membranes, Molecular dynamics -- Computer simulation, Lipid membranes -- Permeability|
|Journal or Publication Title:||Journal of the American Chemical Society|
|Publisher:||American Chemical Society|
|Official Date:||1 November 2006|
|Page Range:||pp. 13982-13983|
|Access rights to Published version:||Restricted or Subscription Access|
|Funder:||Engineering and Physical Sciences Research Council (EPSRC), Unilever (Firm), EU Network of Excellence SoftComp|
(1) Yu, Z. W.; Quinn, P. J. Mol. Membr. Biol. 1998, 15, 59-68 .
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