Towards a mechanical model of skin : insights into stratum corneum mechanical properties from hierarchical models of lipid organisation
O'Malley, B. (Brendan), Moore, D. J., Noro, Massimo, 1968-, Anwar, Jamshed, Notman, Rebecca, Dauskhardt, R. and Bedford, E. (2005) Towards a mechanical model of skin : insights into stratum corneum mechanical properties from hierarchical models of lipid organisation. In: Symposium on Mechanical Properties of Bioinspired and Biological Materials held at the 2004 MRS Fall Meeting, Boston, MA, 29 Nov - 2 Dec 2004. Published in: Materials Research Society Symposium Proceedings, Vol.844 pp. 167-172.Full text not available from this repository.
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The stratum corneum (SC), the outermost layer of the skin, provides the body with a physiologically essential barrier to unregulated water loss and the influx of exogenous substances. Furthermore, the 10-20 micron thick SC, composed of overlapping protein-rich corneocytes surrounded by a heterogeneous multilamellar lipid matrix, displays tremendous mechanical cohesion and thermal integrity. To understand the contribution of these components to SC mechanical properties requires building a complete mechanical model of the skin. In this study we focus on modelling the hierarchical microstructure of the lipid phase and its relation to mechanical properties using a combination of atomistic and mesoscale simulations. The modelling approaches are parameterised with experimental data from FT-IR spectroscopy, X-ray scattering and, in the case of the mesoscale simulations, with detailed density profiles derived from atomic models. The atomistic models are used to probe the role of specific lipid species in maintaining the thermal and structural stability of the SC extracellular lipid matrix and to investigate the role of hydrogen bonding networks in SC lipid cohesion. Mesoscale models are used to investigate domain formation and lipid bilayer organisation on length and time scales inaccessible with atomistic models. These coarse grained models display transitions between ordered hexagonal gel phases and fluid phases, reproducing the experimentally observed ordering of the hydrophilic and hydrophobic regions.
|Item Type:||Conference Item (Paper)|
|Subjects:||Q Science > QD Chemistry
Q Science > QP Physiology
|Divisions:||Faculty of Science > Chemistry|
|Library of Congress Subject Headings (LCSH):||Epidermis -- Mechanical properties, Lipids -- Microstructure -- Simulation methods, Bilayer lipid membranes|
|Journal or Publication Title:||Materials Research Society Symposium Proceedings|
|Publisher:||Materials Research Society|
|Page Range:||pp. 167-172|
|Access rights to Published version:||Restricted or Subscription Access|
|Conference Paper Type:||Paper|
|Title of Event:||Symposium on Mechanical Properties of Bioinspired and Biological Materials held at the 2004 MRS Fall Meeting|
|Type of Event:||Other|
|Location of Event:||Boston, MA|
|Date(s) of Event:||29 Nov - 2 Dec 2004|
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