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Cell-based acoustic sensors for biomedical applications
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Cole, Marina, Gardner, J. W. (Julian W.), 1958-, Pathak, S., Racz, Z., Challiss, R. A. J. (R. A. John) and Markovic, D. (2010) Cell-based acoustic sensors for biomedical applications. In: IASTED International Conference on Biomedical Engineering, Innsbruck, Austria, 17-19 Feb 2010. Published in: Proceedings of 7th IASTED International Conference on Biomedical Engineering, Vol.1-2 pp. 195-201.
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Official URL: http://www.actapress.com/Abstract.aspx?paperId=384...
Abstract
The development of a novel surface acoustic wave biosensor for liquid phase ligand detection is described in this paper. The functional layer of the biosensor comprises human embryonic kidney cells that can be efficiently used for the expression of specific ligand receptors and is coupled to the acousto-electric transducer. We outline the successful design and development of a low loss shear horizontal surface acoustic wave device for detection of receptor-ligand interactions in heterologous systems. The proof of concept implementation of a protocol to immobilize cells expressing either muscarinic acetylcholine or insect olfactory receptors on the device surface has been successful. In addition, the background effect of the cell growth medium has been examined and results presented. We believe that this biological sensor also can be used more generally to monitor cell viability when challenged with toxins, drugs or other substances.
| Item Type: | Conference Item (Paper) |
|---|---|
| Subjects: | R Medicine > R Medicine (General) T Technology > TK Electrical engineering. Electronics Nuclear engineering |
| Divisions: | Faculty of Science > Engineering |
| Library of Congress Subject Headings (LCSH): | Biosensors, Biomedical engineering, Acoustic surface wave devices, Ligands (Biochemistry) |
| Journal or Publication Title: | Proceedings of 7th IASTED International Conference on Biomedical Engineering |
| Publisher: | ACTA Press |
| ISSN: | 9780889868250 |
| Date: | 2010 |
| Volume: | Vol.1-2 |
| Page Range: | pp. 195-201 |
| Status: | Not Peer Reviewed |
| Publication Status: | Published |
| Conference Paper Type: | Paper |
| Title of Event: | IASTED International Conference on Biomedical Engineering |
| Type of Event: | Conference |
| Location of Event: | Innsbruck, Austria |
| Date(s) of Event: | 17-19 Feb 2010 |
| URI: | http://wrap.warwick.ac.uk/id/eprint/40645 |
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