1. Projan SJ: New (and not so new) antibacterial targets – from
where and when will the novel drugs come? Curr Opin Pharmacol
2002, 2:513-522.
2. Young KD: Bacterial shape. Mol Microbiol 2003, 49:571-580.
3. El Zoeiby A, Sanschagrin F, Levesque RC: Structure and function
of the Mur enzymes: development of novel inhibitors. Mol
Microbiol 2003, 47:1-12.
4. Silver LL: Novel inhibitors of bacterial cell wall synthesis. Curr
Opin Microbiol 2003, 6:431-438.
5. Bugg TD, Walsh CT: Intracellular steps of bacterial cell wall
peptidoglycan biosynthesis: enzymology, antibiotics, and
antibiotic resistance. Nat Prod Rep 1992, 9:199-215.
6. Anderson MS, Eveland SS, Onishi HR, Pompliano DL: Kinetic mechanism
of the Escherichia coli UDPMurNAc-tripeptide D-alanyl-
D-alanine-adding enzyme: use of a glutathione Stransferase
fusion. Biochemistry 1996, 35:16264-16269.
7. Mengin-Lecreulx D, van Heijenoort J, Park JT: Identification of the
mpl gene encoding UDP-N-acetylmuramate: L-alanylgamma-
D-glutamyl-meso-diaminopimelate ligase in
Escherichia coli and its role in recycling of cell wall peptidoglycan.
J Bacteriol 1996, 178:5347-5352.
8. Lugtenberg EJ, v Schijndel-van Dam A: Temperature-sensitive
mutants of Escherichia coli K-12 with low activities of the Lalanine
adding enzyme and the D-alanyl-D-alanine adding
enzyme. J Bacteriol 1972, 110:35-40.
9. Sobral RG, Ludovice AM, de Lencastre H, Tomasz A: Role of murF
in cell wall biosynthesis: isolation and characterization of a
murF conditional mutant of Staphylococcus aureus. J Bacteriol
2006, 188:2543-2553.
10. Baum EZ, Crespo-Carbone SM, Abbanat D, Foleno B, Maden A, Goldschmidt
R, Bush K: Utility of muropeptide ligase for identification
of inhibitors of the cell wall biosynthesis enzyme MurF.
Antimicrob Agents Chemother 2006, 50:230-236.
11. Walsh CT: Enzymes in the D-alanine branch of bacterial cell
wall peptidoglycan assembly. J Biol Chem 1989, 264:2393-2396.
12. Holtje JV: Growth of the stress-bearing and shape-maintaining
murein sacculus of Escherichia coli. Microbiol Mol Biol Rev
1998, 62:181-203.
13. Sobral RG, Ludovice AM, Gardete S, Tabei K, De Lencastre H,
Tomasz A: Normally functioning murF is essential for the
optimal expression of methicillin resistance in Staphylococcus
aureus. Microb Drug Resist 2003, 9:231-241.
14. Bugg TD, Wright GD, Dutka-Malen S, Arthur M, Courvalin P, Walsh
CT: Molecular basis for vancomycin resistance in Enterococcus
faecium BM4147: biosynthesis of a depsipeptide peptidoglycan
precursor by vancomycin resistance proteins VanH
and VanA. Biochemistry 1991, 30:10408-10415.
15. Reynolds PE: Structure, biochemistry and mechanism of
action of glycopeptide antibiotics. Eur J Clin Microbiol Infect Dis
1989, 8:943-950.
16. Christensen DJ, Gottlin EB, Benson RE, Hamilton PT: Phage display
for target-based antibacterial drug discovery. Drug Discov
Today 2001, 6:721-727.
17. El Zoeiby A, Sanschagrin F, Darveau A, Brisson JR, Levesque RC:
Identification of novel inhibitors of Pseudomonas aeruginosa
MurC enzyme derived from phage-displayed peptide libraries.
J Antimicrob Chemother 2003, 51:531-543.
18. Paradis-Bleau C, Beaumont M, Boudreault L, Lloyd A, Sanschagrin F,
Bugg TD, Levesque RC: Selection of peptide inhibitors against
the Pseudomonas aeruginosa MurD cell wall enzyme. Peptides
2006.
19. Davies JC: Pseudomonas aeruginosa in cystic fibrosis: pathogenesis
and persistence. Paediatr Respir Rev 2002, 3:128-134.
20. Pierce GE: Pseudomonas aeruginosa, Candida albicans, and
device-related nosocomial infections: implications, trends,
and potential approaches for control. J Ind Microbiol Biotechnol
2005, 32:309-318.
21. El Zoeiby A, Sanschagrin F, Havugimana PC, Garnier A, Levesque RC:
In vitro reconstruction of the biosynthetic pathway of peptidoglycan
cytoplasmic precursor in Pseudomonas aeruginosa.
FEMS Microbiol Lett 2001, 201:229-235.
22. Comb DG: The enzymatic addition of D-alanyl-D-alanine to a
uridine nucleotide-peptide. J Biol Chem 1962, 237:1601-1604.
23. Paradis-Bleau C, Sanschagrin F, Levesque RC: Peptide inhibitors of
the essential cell division protein FtsA. Protein Eng Des Sel 2005,
18:85-91.
24. Paradis-Bleau C, Sanschagrin F, Levesque RC: Identification of
Pseudomonas aeruginosa FtsZ peptide inhibitors as a tool
for development of novel antimicrobials. J Antimicrob Chemother
2004, 54:278-280.
25. Egan A, Lawrence P, Strominger JL: Enzymatic synthesis of the
peptide in bacterial ridine nucleotides. V. Co ++ -dependent
reversal of peptide bond formation. J Biol Chem 1973,
248:3122-3130.
26. Neuhaus FC, Struve WG: Enzymatic Synthesis of Analogs of the
Cell-Wall Precursor. I. Kinetics and Specificity of Uridine
Diphospho-N-Acetylmuramyl-L-Alanyl-D-Glutamyl-LLysine:
D-Alanyl-D-Alanine Ligase (Adenosine Diphosphate)
from Streptococcus Faecalis R. Biochemistry 1965, 4:120-131.
27. Michaud C, Blanot D, Flouret B, Van Heijenoort J: Partial purification
and specificity studies of the D-glutamate-adding and Dalanyl-
D-alanine-adding enzymes from Escherichia coli K12.
Eur J Biochem 1987, 166:631-637.
28. Dementin S, Bouhss A, Auger G, Parquet C, Mengin-Lecreulx D,
Dideberg O, van Heijenoort J, Blanot D: Evidence of a functional
requirement for a carbamoylated lysine residue in MurD,
MurE and MurF synthetases as established by chemical rescue
experiments. Eur J Biochem 2001, 268:5800-5807.
29. Mengin-Lecreulx D, Flouret B, van Heijenoort J: Cytoplasmic steps
of peptidoglycan synthesis in Escherichia coli. J Bacteriol 1982,
151:1109-1117.
30. Mengin-Lecreulx D, Blanot D, van Heijenoort J: Replacement of
diaminopimelic acid by cystathionine or lanthionine in the
peptidoglycan of Escherichia coli. J Bacteriol 1994,
176:4321-4327.
31. Lugtenberg EJ: Studies on Escherichia coli enzymes involved in
the synthesis of uridine diphosphate-N-acetyl-muramyl-pentapeptide.
J Bacteriol 1972, 110:26-34.
32. Duncan K, van Heijenoort J, Walsh CT: Purification and characterization
of the D-alanyl-D-alanine-adding enzyme from
Escherichia coli. Biochemistry 1990, 29:2379-2386.
33. Eveland SS, Pompliano DL, Anderson MS: Conditionally lethal
Escherichia coli murein mutants contain point defects that
map to regions conserved among murein and folyl polygamma-
glutamate ligases: identification of a ligase superfamily.
Biochemistry 1997, 36:6223-6229.
34. Azzolina BA, Yuan X, Anderson MS, El-Sherbeini M: The cell wall
and cell division gene cluster in the Mra operon of Pseudomonas
aeruginosa: cloning, production, and purification of
active enzymes. Protein Expr Purif 2001, 21:393-400.
35. Gu YG, Florjancic AS, Clark RF, Zhang T, Cooper CS, Anderson DD,
Lerner CG, McCall JO, Cai Y, Black-Schaefer CL, Stamper GF, Hajduk
PJ, Beutel BA: Structure-activity relationships of novel potent
MurF inhibitors. Bioorg Med Chem Lett 2004, 14:267-270.
36. Comess KM, Schurdak ME, Voorbach MJ, Coen M, Trumbull JD, Yang
H, Gao L, Tang H, Cheng X, Lerner CG, McCall JO, Burns DJ, Beutel
BA: An ultraefficient affinity-based high-throughout screening
process: application to bacterial cell wall biosynthesis
enzyme MurF. J Biomol Screen 2006, 11:743-754.
37. Miller DJ, Hammond SM, Anderluzzi D, Bugg TDH: Aminoalkylphosphinate
inhibitors of D-Ala-D-Ala adding enzyme. J
Chem Soc Perkin Trans 1998, 1:131-142.
38. Bouhss A, Mengin-Lecreulx D, Blanot D, van Heijenoort J, Parquet C:
Invariant amino acids in the Mur peptide synthetases of bacterial
peptidoglycan synthesis and their modification by sitedirected
mutagenesis in the UDP-MurNAc:L-alanine ligase
from Escherichia coli. Biochemistry 1997, 36:11556-11563.
39. Bertrand JA, Fanchon E, Martin L, Chantalat L, Auger G, Blanot D, van
Heijenoort J, Dideberg O: "Open" structures of MurD: domain
movements and structural similarities with folylpolyglutamate
synthetase. J Mol Biol 2000, 301:1257-1266.
40. Yan Y, Munshi S, Leiting B, Anderson MS, Chrzas J, Chen Z: Crystal
structure of Escherichia coli UDPMurNAc-tripeptide d-alanyl-
d-alanine-adding enzyme (MurF) at 2.3 A resolution. J
Mol Biol 2000, 304:435-445.
41. Cornish-Bowden A: Fundamentals of enzyme kinetics London; Boston:
Butterworths; 1979.
42. Segal IH: Enzyme kinetics – behavior and analysis of rapid equilibrium and
steady-state enzyme systems John Wiley and Sons, Inc; 1993.
43. Nefzi A, Dooley C, Ostresh JM, Houghten RA: Combinatorial
chemistry: from peptides and peptidomimetics to small
organic and heterocyclic compounds. Bioorg Med Chem Lett
1998, 8:2273-2278.
44. Walker JM: The proteomics protocols handbook Totowa, N.J.: Humana
Press; 2005.
45. Jones DT: Protein secondary structure prediction based on
position-specific scoring matrices. J Mol Biol 1999, 292:195-202.
46. Mackey AJ, Haystead TA, Pearson WR: Getting more from less:
algorithms for rapid protein identification with multiple
short peptide sequences. Mol Cell Proteomics 2002, 1:139-147.
47. Reddy SG, Waddell ST, Kuo DW, Wong KK, Pompliano DL: Preparative
Enzymatic Synthesis and Characterization of the Cytoplasmic
Intermediates of Murein Biosynthesis. Journal of the
American Chemical Society 1999, 121:1175-1178.
48. Lanzetta PA, Alvarez LJ, Reinach PS, Candia OA: An improved
assay for nanomole amounts of inorganic phosphate. Anal Biochem
1979, 100:95-97.