Allen Brain Atlas, available at: www.brain-map.org.
American Psychiatric Association, 1994. Diagnostic and Statistical Manual
of Mental Disorders, fourth ed. American Psychiatric Association,
Washington, DC.
Antúnez, C., Boada, M., López-Arrieta, J., Ramirez-Lorca, R., Hernández,
I., Marín, J., Martínez-Lage, P., González-Pérez, A., Jorge Galan, J.,
Gayán, J., Real, L.M., Ruiz, A., 2009. GOLPH2 gene markers are not
associated with Alzheimer’s disease in a sample of the Spanish population.
J. Alzheimers Dis. 18, 751–754.
Bachert, C., Fimmel, C., Linstedt, A.D., 2007. Endosomal trafficking and
proprotein convertase cleavage of cis Golgi protein GP73 produces
marker for hepatocellular carcinoma. Traffic 8, 1415–1423.
Badre, D., Wagner, A.D., 2007. Left ventrolateral prefrontal cortex and the
cognitive control of memory. Neuropsychologia 45, 2883–2901.
Barnes, J., Bartlett, J.W., van de Pol, L.A., Loy, C.T., Scahill, R.I., Frost,
C., Thompson, P., Fox, N.C., 2009. A meta-analysis of hippocampal
atrophy rates in Alzheimer’s disease. Neurobiol. Aging 30, 1711–1723.
Barrett, J.C., Fry, B., Maller, J., Daly, M.J., 2005. Haploview: analysis and
visualization of LD and haplotype maps. Bioinformatics 21, 263–265.
Blacker, D., Bertram, L., Saunders, A.J., Moscarillo, T.J., Albert, M.S.,
Wiener, H., Perry, R.T., Collins, J.S., Harrell, L.E., Go, R.C., Mahoney,
A., Beaty, T., Fallin, M.D., Avramopoulos, D., Chase, G.A.,
Folstein, M.F., McInnis, M.G., Bassett, S.S., Doheny, K.J., Pugh, E.W.,
Tanzi, R.E., NIMH Genetics Initiative Alzheimer’s Disease Study
Group, 2003. Results of a high-resolution genome screen of 437 Alzheimer’s
disease families. Hum. Mol. Genet. 12, 23–32.
Boccardi, M., Sabattoli, F., Testa, C., Beltramello, A., Soininen, H.,
Frisoni, G.B., 2004. APOE and modulation of Alzheimer’s and frontotemporal
dementia. Neurosci. Lett. 356, 167–170.
Chan, D., Janssen, J.C., Whitwell, J.L., Watt, H.C., Jenkins, R., Frost, C.,
Rossor, M.N., Fox, N.C., 2003. Change in rates of cerebral atrophy
over time in early-onset Alzheimer’s disease: longitudinal MRI study.
Lancet 362, 1121–1122.
Curtis, D., North, B.V., Sham, P.C., 2001. A novel method of two-locus
linkage analysis applied to a genome scan for late onset Alzheimer’s
disease. Ann. Hum. Genet. 65 (Pt 5), 473–481.
Filippini, N., Rao, A., Wetten, S., Gibson, R.A., Borrie, M., Guzman, D.,
Kertesz, A., Loy-English, I., Williams, J., Nichols, T., Whitcher, B.,
Matthews, P.M., 2009. Anatomically-distinct genetic associations of
Apoe e4 allele load with regional cortical atrophy in Alzheimer’s
disease. Neuroimage 44, 724–728.
Folstein, M.F., Folstein, S.E., McHugh, P.R., 1975. “Mini-mental state”. A
practical method for grading the cognitive state of patients for the
clinician. J. Psychiatr. Res. 12, 189–198.
Geroldi, C., Pihlajamaki, M., Laakso, M.P., deCarli, C., Beltramello, A.,
Bianchetti, A., Soininen, H., Trabucchi, M., Frisoni, G.B., 1999.
APOE-epsilon4 is associated with less frontal and more medial temporal
lobe atrophy in AD. Neurology 53, 1825–1832.
Good, C.D., Johnsrude, I.S., Ashburner, J., Henson, R.N., Friston, K.J.,
Frackowiak, R.S., 2001. A voxel-based morphometric study of ageing
in 465 normal adult human brains. Neuroimage 14, 21–36.
Hashimoto, M., Yasuda, M., Tanimukai, S., Matsui, M., Hirono, N., Kazui,
H., Mori, E., 2001. Apolipoprotein E epsilon 4 and the pattern of
regional brain atrophy in Alzheimer’s disease. Neurology 57, 1461–
1466.
Hayasaka, S., Phan, K.L., Liberzon, I., Worsley, K.J., Nichols, T.E., 2004.
Nonstationary cluster- size inference with random field and permutation
methods. Neuroimage 22, 676–687.
Holmans, P., Hamshere, M., Hollingworth, P., Rice, F., Tunstall, N., Jones,
S., Moore, P., Wavrant DeVrieze, F., Myers, A., Crooks, R., Compton,
D., Marshall, H., Meyer, D., Shears, S., Booth, J., Ramic, D., Williams,
N., Norton, N., Abraham, R., Kehoe, P., Williams, H., Rudrasingham,
V., O’Donovan, M., Jones, L., Hardy, J., Goate, A., Lovestaone, S.,
Owen, M., Williams, J., 2005. Genome screen for loci influencing age
at onset and rate of decline in late onset Alzheimer’s disease. Am. J.
Med. Genet. B Neuropsychiatr. Genet. 135B, 24–32.
Hu, Z., Zeng, L., Huang, Z., Zhang, J., Li, T., 2007. The study of golgi
apparatus in alzheimer’s disease. Neurochem. Res. 32, 1265–1277.
Inkster, B., Nichols, T.E., Saemann, P.G., Auer, D.P., Holsboer, F., Muglia,
P., Matthews, P.M., 2009. Association of GSK3beta polymorphisms
with brain structural changes in major depressive disorder.
Arch. Gen. Psychiatry 66, 721–728.
Ioannidis, J.P., Trikalinos, T.A., Khoury, M.J., 2006. Implications of small
effect sizes of individual genetic variants on the design and interpretation
of genetic association studies of complex diseases. Am. J. Epidemiol.
164, 609–614.
Jack, C.R., Jr, Petersen, R.C., Xu, Y., O’Brien, P.C., Smith, G.E., Ivnik,
R.J., Boeve, B.F., Tangalos, E.G., Kokmen, E., 2000. Rates of hippocampal
atrophy correlate with change in clinical status in aging and
AD. Neurology 55, 484–489.
Judas, M., Cepanec, M., 2007. Adult structure and development of the
human fronto-opercular cerebral cortex (Broca’s region). Clin. Linguist.
Phon. 21, 975–989.
Kladney, R.D., Bulla, G.A., Guo, L., Mason, A.L., Tollefson, A.E., Simon,
D.J., Koutoubi, Z., Fimmel, C.J., 2000. GP73, a novel Golgi-localized
protein upregulated by viral infection. Gene 249, 53–65.
Lee, J.H., Cheng, R., Santana, V., Williamson, J., Lantigua, R., Medrano, M.,
Arriaga, A., Stern, Y., Tycko, B., Rogaeva, E., Wakutani, Y., Kawarai, T.,
St George-Hyslop, P., Mayeux, R., 2006. Expanded genomewide scan
implicates a novel locus at 3q28 among Caribbean hispanics with familial
Alzheimer disease. Arch. Neurol. 63, 1591–1598.
Lehtovirta, M., Laakso, M.P., Soininen, H., Helisalmi, S., Mannermaa, A.,
Helkala, E.L., Partanen, K., Ryynanen, M., Vainio, P., Hartikainen, P.,
et al., 1995. Volumes of hippocampus, amygdala and frontal lobe in
Alzheimer patients with different apolipoprotein E genotypes. Neuroscience
67, 65–72.
Lehtovirta, M., Soininen, H., Laakso, M.P., Partanen, K., Helisalmi, S.,
Mannermaa, A., Ryynanen, M., Kuikka, J., Hartikainen, P., Riekkinen,
P.J. Sr., 1996. SPECT and MRI analysis in Alzheimer’s disease: relation
to apolipoprotein E epsilon 4 allele. J. Neurol. Neurosurg.
Psychiatry 60, 644–649.
Li, H., Wetten, S., Li, L., St. Jean, P.L., Upmanyu, R., Surh, L., Hosford,
D., Barnes, M.R., Briley, J.D., Borrie, M., Coletta, N., Delisle, R.,
Dhalla, D., Ehm, M.G., Feldman, H.H., Fornazzari, L., Gauthier, S.,
Goodgame, N., Guzman, D., Hammond, S., Hollingworth, P., Hsiung,
G.Y., Johnson, J., Kelly, D.D., Keren, R., Kertesz, A., King, K.S.,
Lovestone, S., Loy-English, I., Matthews, P.M., Owen, M.J., Plumpton,
M., Pryse-Phillips, W., Prinjha, R.K., Richardson, J.C., Saunders,
A., Slater, A.J., St. George-Hyslop, P.H., Stinnett, S.W., Swartz, J.E.,
Taylor, R.L., Wherrett, J., Williams, J., Yarnall, D.P., Gibson, R.A.,
Irizarry, M.C., Middleton, L.T., Roses, A.D., 2008. Candidate singlenucleotide
polymorphisms from a genomewide association study of
Alzheimer disease. Arch. Neurol. 65, 45–53.
McDonalds, C.R., McEvoy, L.K., Gharapetian, L., Fennema-Notestine, C.,
Hagler, D.J., Jr, Holland, D., Koyama, A., Brewer, J.B., Dale, A.M.,
Alzheimer’s Disease Neuroimaging Initiative, 2009. Regional rates of
neocortical atrophy from normal aging to Alzheimer’s disease. Neurology
73, 457–465.
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., Stadlan,
E.M., 1984. Clinical diagnosis of Alzheimer’s disease: report of the
NINCDS-ADRDA Work Group under the auspices of Department of
Health and Human Services Task Force on Alzheimer’s Disease. Neurology
34, 939–944.
Mudge, J., Miller, N.A., Khrebtukova, I., Lindquist, I.E., May, G.D.,
Huntley, J.J., Luo, S., Zhang, L., van Velkinburgh, J.C., Farmer, A.D.,
Lewis, S., Beavis, W.D., Schilkey, F.D., Virk, S.M., Black, C.F.,
Myers, M.K., Mader, L.C., Langley, R.J., Utsey, J.P., Kim, R.W.,
Roberts, R.C., Khalsa, S.K., Garcia, M., Ambriz-Griffith, V., Harlan,
R., Czika, W., Martin, S., Wolfinger, R.D., Perrone-Bizzozero, N.I.,
Schroth, G.P., Kingsmore, S.F., 2008. Genomic convergence analysis
of schizophrenia: mRNA sequencing reveals altered synaptic vesicular
transport in post-mortem cerebellum. PLoS One 3, e3625.
Muglia, P., Tozzi, F., Galwey, N.W., Francks, C., Upmanyu, R., Kong,
X.Q., Antoniades, A., Domenici, E., Perry, J., Rothen, S., Vandeleur,
C.L., Mooser, V., Waeber, G., Vollenweider, P., Preisig, M., Lucae, S.,
Müller-Myhsok, B., Holsboer, F., Middleton, L.T., Roses, A.D., 2008.
Genome-wide association study of recurrent major depressive disorder
in two European case-control cohorts. Mol. Psychiatry, in press. PMID:
19107115.
Myers, A., Wavrant De-Vrieze, F., Holmans, P., Hamshere, M., Crook, R.,
Compton, D., Marshall, H., Meyer, D., Shears, S., Booth, J., Ramic, D.,
Knowles, H., Morris, J.C., Williams, N., Norton, N., Abraham, R.,
Kehoe, P., Williams, H., Rudrasingham, V., Rice, F., Giles, P., Tunstall,
N., Jones, L., Lovestone, S., Williams, J., Owen, M.J., Hardy, J.,
Goate, A., 2002. Full genome screen for Alzheimer disease: stage II
analysis. Am. J. Med. Genet. 114, 235–244.
Nichols, T., Hayasaka, S., 2003. Controlling the familywise error rate in
functional neuroimaging: a comparative review. Stat. Methods Med.
Res. 12, 419–446.
Olson, J.M., Goddard, K.A., Dudek, D.M., 2002. A second locus for
very-late-onset Alzheimer disease: a genome scan reveals linkage to
20p and epistasis between 20p and the amyloid precursor protein
region. Am. J. Hum. Genet. 71, 154–161.
Pericak-Vance, M.A., Grubber, J., Bailey, L.R., Hedges, D., West, S.,
Santoro, L., Kemmerer, B., Hall, J.L., Saunders, A.M., Roses, A.D.,
Small, G.W., Scott, W.K., Conneally, P.M., Vance, J.M., Haines, J.L.,
2000. Identification of novel genes in late-onset Alzheimer’s disease.
Exp. Gerontol. 35, 1343–1352.
Puri, S., Bachert, C., Fimmel, C.J., Linstedt, A.D., 2002. Cycling of early
Golgi proteins via the cell surface and endosomes upon lumenal pH
disruption. Traffic 3, 641–653.
Schjeide, B.M., Hooli, B., Parkinson, M., Hogan, M.F., DiVito, J., Mullin,
K., Blacker, D., Tanzi, R.E., Bertram, L., 2009. GAB2 as an Alzheimer
disease susceptibility gene: follow-up of genomewide association results.
Arch. Neurol. 66, 250–254.
Su, A.I., Wiltshire, T., Batalov, S., Lapp, H., Ching, K.A., Block, D.,
Zhang, J., Soden, R., Hayakawa, M., Kreiman, G., Cooke, M.P.,
Walker, J.R., Hogenesch, J.B., 2004. A gene atlas of the mouse and
human protein-encoding transcriptomes. Proc. Natl. Acad. Sci. U. S. A.
101, 6062–6067.
Tanaka, S., Kawamata, J., Shimohama, S., Akaki, H., Akiguchi, I., Kimura,
J., Ueda, K., 1998. Inferior temporal lobe atrophy and APOE genotypes
in Alzheimer’s disease. X-ray computed tomography, magnetic resonance
imaging and Xe-133 SPECT studies. Dement. Geriatr. Cogn.
Disord. 9, 90–98.
Thompson, P.M., Hayashi, K.M., Dutton, R.A., Chiang, M.C., Leow, A.D.,
Sowell, E.R., De Zubicaray, G., Becker, J.T., Lopez, O.L., Aizenstein,
H.J., Toga, A.W., 2007. Tracking Alzheimer’s disease. Ann. N.Y.
Acad. Sci. 1097, 183–214.
Tozzi, F., Prokopenko, I., Perry, J.D., Kennedy, J.L., McCarthy, A.D.,
Holsboer, F., Berrettini, W., Middleton, L.T., Chilcoat, H.D., Muglia,
P., 2008. Family history of depression is associated with younger age
of onset in patients with recurrent depression. Psychol. Med. 38, 641–
649.
Tzourio-Mazoyer, N., Landbeau, B., Papathanassiou, D., Crivello, F.,
Etard, O., Delcroix, N., Mazoyer, B., Joliot, M., 2002. Automated
anatomical labeling of activations in SPM using a macroscopic anatomical
parcellation of the MNI MRI single-subject brain. Neuroimage
15, 273–289.