(2012) Genetic variation in GOLM1 and prefrontal cortical volume in Alzheimer's disease. Neurobiology of Aging, Vol.33 (No.3). pp. 457-465. ISSN 0197-4580

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Abstract

Replications of the association between APOE-ε4 allele load and regional brain atrophy in Alzheimer's disease (AD) patients hold promise for future studies testing relationships between other disease risk gene variants and brain structure. A polymorphism, rs10868366, in the Golgi phosphoprotein 2 gene, GOLM1, was recently identified as an AD risk factor in a genome-wide association study. In a subset of the same AD cohort, we used voxel-based morphometry to test for association between the disease risk genotype and reduced regional gray matter (GM) volume in AD patients (n = 72). A mean 14% reduction in GM volume was observed in the left frontal gyrus with the higher risk GG genotype. A similar association was observed in an independent, dataset of nondemented subjects (n = 278), although with a smaller effect (1%). This replicated association with GM structural variation suggests that GOLM1 polymorphisms may be related to cognitive phenotypes. The greater effect size in AD patients also suggests that the GG genotype could be a risk factor for the expression of cognitive deficits in AD.

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Item Type:	Submitted Journal Article
Subjects:	Q Science > QP Physiology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions:	Faculty of Science > Statistics Faculty of Medicine > Warwick Medical School Faculty of Science > WMG (Formerly the Warwick Manufacturing Group)
Library of Congress Subject Headings (LCSH):	Prefrontal cortex, Alzheimer's disease, Brain -- Degeneration
Journal or Publication Title:	Neurobiology of Aging
Publisher:	Elsevier Inc.
ISSN:	0197-4580
Date:	March 2012
Volume:	Vol.33
Number:	No.3
Number of Pages:	19
Page Range:	pp. 457-465
Identification Number:	10.1016/j.neurobiolaging.2010.04.018
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	GlaxoSmithKline
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URI:	http://wrap.warwick.ac.uk/id/eprint/41130

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