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Genetic variation in GOLM1 and prefrontal cortical volume in Alzheimer's disease
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(2012) Genetic variation in GOLM1 and prefrontal cortical volume in Alzheimer's disease. Neurobiology of Aging, Vol.33 (No.3). pp. 457-465. doi:10.1016/j.neurobiolaging.2010.04.018 ISSN 0197-4580.
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Official URL: http://dx.doi.org/10.1016/j.neurobiolaging.2010.04...
Abstract
Replications of the association between APOE-ε4 allele load and regional brain atrophy in Alzheimer's disease (AD) patients hold promise for future studies testing relationships between other disease risk gene variants and brain structure. A polymorphism, rs10868366, in the Golgi phosphoprotein 2 gene, GOLM1, was recently identified as an AD risk factor in a genome-wide association study. In a subset of the same AD cohort, we used voxel-based morphometry to test for association between the disease risk genotype and reduced regional gray matter (GM) volume in AD patients (n = 72). A mean 14% reduction in GM volume was observed in the left frontal gyrus with the higher risk GG genotype. A similar association was observed in an independent, dataset of nondemented subjects (n = 278), although with a smaller effect (1%). This replicated association with GM structural variation suggests that GOLM1 polymorphisms may be related to cognitive phenotypes. The greater effect size in AD patients also suggests that the GG genotype could be a risk factor for the expression of cognitive deficits in AD.
| Item Type: | Journal Article | ||||
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| Subjects: | Q Science > QP Physiology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Statistics Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School Faculty of Science, Engineering and Medicine > Engineering > WMG (Formerly the Warwick Manufacturing Group) |
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| Library of Congress Subject Headings (LCSH): | Prefrontal cortex, Alzheimer's disease, Brain -- Degeneration | ||||
| Journal or Publication Title: | Neurobiology of Aging | ||||
| Publisher: | Elsevier Inc. | ||||
| ISSN: | 0197-4580 | ||||
| Official Date: | March 2012 | ||||
| Dates: |
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| Volume: | Vol.33 | ||||
| Number: | No.3 | ||||
| Number of Pages: | 19 | ||||
| Page Range: | pp. 457-465 | ||||
| DOI: | 10.1016/j.neurobiolaging.2010.04.018 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | GlaxoSmithKline |
Data sourced from Thomson Reuters' Web of Knowledge
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