Dixson, Luanna, Ridler, Khanum, Nichols, Thomas E., Saemann, Philipp G., Auer, Dorothee P., Holsboer, Florian, Muglia, Pierandrea, Matthews, Paul M. and Inkster, Becky. (2011) Thyroid hormone transporter genes and grey matter changes in patients with major depressive disorder and healthy controls. Psychoneuroendocrinology, Vol.36 (No.6). pp. 929-934. ISSN 0306-4530

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Abstract

Several studies have established links between thyroid gland dysfunction and mood disorders, in particular major depressive disorder (MDD). Preliminary evidence also suggests that thyroid hormone gene variants influence grey matter (GM) volume, which is reportedly altered in patients with MDD. This study tested for associations of single nucleotide polymorphisms (SNPs) in two thyroid hormone transporter genes with regional GM volume differences in a large sample population of patients with recurrent MDD and healthy volunteers.

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Item Type:	Journal Article
Subjects:	Q Science > QH Natural history > QH426 Genetics Q Science > QP Physiology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions:	Faculty of Science > Statistics Faculty of Science > WMG (Formerly the Warwick Manufacturing Group)
Library of Congress Subject Headings (LCSH):	Thyroid hormones, Brain -- Magnetic resonance imaging, Depression, Mental, Genetic polymorphisms
Journal or Publication Title:	Psychoneuroendocrinology
Publisher:	Pergamon
ISSN:	0306-4530
Date:	2011
Volume:	Vol.36
Number:	No.6
Page Range:	pp. 929-934
Identification Number:	10.1016/j.psyneuen.2010.12.002
Status:	Peer Reviewed
Publication Status:	Published
Funder:	GlaxoSmithKline
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URI:	http://wrap.warwick.ac.uk/id/eprint/41132

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