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Thyroid hormone transporter genes and grey matter changes in patients with major depressive disorder and healthy controls
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Dixson, Luanna, Ridler, Khanum, Nichols, Thomas E., Saemann, Philipp G., Auer, Dorothee P., Holsboer, Florian, Muglia, Pierandrea, Matthews, Paul M. and Inkster, Becky (2011) Thyroid hormone transporter genes and grey matter changes in patients with major depressive disorder and healthy controls. Psychoneuroendocrinology, Vol.36 (No.6). pp. 929-934. doi:10.1016/j.psyneuen.2010.12.002
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Official URL: http://dx.doi.org/10.1016/j.psyneuen.2010.12.002
Abstract
Several studies have established links between thyroid gland dysfunction and mood disorders, in particular major depressive disorder (MDD). Preliminary evidence also suggests that thyroid hormone gene variants influence grey matter (GM) volume, which is reportedly altered in patients with MDD. This study tested for associations of single nucleotide polymorphisms (SNPs) in two thyroid hormone transporter genes with regional GM volume differences in a large sample population of patients with recurrent MDD and healthy volunteers.
| Item Type: | Journal Article | ||||
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| Subjects: | Q Science > QH Natural history > QH426 Genetics Q Science > QP Physiology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Statistics Faculty of Science, Engineering and Medicine > Engineering > WMG (Formerly the Warwick Manufacturing Group) |
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| Library of Congress Subject Headings (LCSH): | Thyroid hormones, Brain -- Magnetic resonance imaging, Depression, Mental, Genetic polymorphisms | ||||
| Journal or Publication Title: | Psychoneuroendocrinology | ||||
| Publisher: | Pergamon | ||||
| ISSN: | 0306-4530 | ||||
| Official Date: | 2011 | ||||
| Dates: |
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| Volume: | Vol.36 | ||||
| Number: | No.6 | ||||
| Page Range: | pp. 929-934 | ||||
| DOI: | 10.1016/j.psyneuen.2010.12.002 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Funder: | GlaxoSmithKline |
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