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A comparison of gray matter density in restless legs syndrome patients and matched controls using voxel-based morphometry
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Comley, Robert A., Cervenka, Simon, Palhagen, Sven E., Panagiotidis, Georgios, Matthews, Julian C., Lai, Robert Y., Halldin, Christer, Farde, Lars, Nichols, Thomas E. and Whitcher, Brandon J. (2012) A comparison of gray matter density in restless legs syndrome patients and matched controls using voxel-based morphometry. Journal of Neuroimaging, Vol.22 (No.1). pp. 28-32. doi:10.1111/j.1552-6569.2010.00536.x ISSN 1051-2284.
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Official URL: http://dx.doi.org/10.1111/j.1552-6569.2010.00536.x
Abstract
BACKGROUND
Restless legs syndrome (RLS) is a common neurological disorder the pathophysiology of which is incompletely understood. Four studies have examined structural differences between the brains of RLS patients and healthy controls, using voxel-based morphometry (VBM). All 4 studies have provided different results.
METHODS
Optimized VBM was used to search for structural differences in gray matter density. Sixteen RLS patients naïve to dopaminergic drugs and 16 age- and sex-matched controls received structural T1-weighted MR scans. Structural data were analyzed using FSL-VBM.
RESULTS
No difference in gray matter density was detected between the two groups (voxel-wise significance: no significant voxels at P= .89 (whole brain Family Wise Error (FWE) corrected); no significant voxels at P < .05 (whole brain False Discovery Rate (FDR) corrected; smallest achievable FDR threshold .99).
CONCLUSION/DISCUSSION
The present study did not replicate (confirm) previous findings of structural brain changes in RLS, but instead supported the findings of a recent study showing a lack of gray matter alteration in an elderly RLS population. More specifically, the results do not support neuronal loss as an underlying disease mechanism in RLS. Potential limitations in the application of VBM are also discussed.
Item Type: | Journal Article | ||||
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Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Statistics Faculty of Science, Engineering and Medicine > Engineering > WMG (Formerly the Warwick Manufacturing Group) |
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Library of Congress Subject Headings (LCSH): | Restless legs syndrome, Brain -- Magnetic resonance imaging | ||||
Journal or Publication Title: | Journal of Neuroimaging | ||||
Publisher: | Wiley-Blackwell Publishing Ltd. | ||||
ISSN: | 1051-2284 | ||||
Official Date: | January 2012 | ||||
Dates: |
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Volume: | Vol.22 | ||||
Number: | No.1 | ||||
Page Range: | pp. 28-32 | ||||
DOI: | 10.1111/j.1552-6569.2010.00536.x | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Funder: | GlaxoSmithKline |
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