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Threshold-free cluster enhancement (TFCE) : improving power and stability of cluster size inference in brain imaging
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Nichols, Thomas E. (2010) Threshold-free cluster enhancement (TFCE) : improving power and stability of cluster size inference in brain imaging. In: Joint Statistical Meeting, Vancouver, Canada, Jul 31 - Aug 5, 2010 (Unpublished)
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Official URL: http://www.amstat.org/meetings/jsm/2010/onlineprog...
Abstract
Cluster size inference, or tests based on the spatial extent of brain imaging signals, is a widely used approach in Functional Magnetic Resonance Imaging (fMRI). Clusters are formed by first applying a cluster-forming threshold, and then the significance is assessed based on the volume of the cluster. While this has been shown to be more powerful than 'voxel-wise' inference (inference based on statistic image magnitude at each volume element) it depends critically on the cluster-forming threshold, u. Small changes to u can split or join clusters and change the significance in unexpected way. We have created a new method that merges clustering information over all possible u's, using permutation resampling methods to obtain valid P-values. While elminating one nuisance parameter (u), our method introduces two new ones. I will show how we used (parametric) random field theory to find
| Item Type: | Conference Item (Lecture) | ||||
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| Subjects: | Q Science > QA Mathematics R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Statistics Faculty of Science, Engineering and Medicine > Engineering > WMG (Formerly the Warwick Manufacturing Group) |
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| Library of Congress Subject Headings (LCSH): | Brain -- Imaging -- Statistical methods | ||||
| Official Date: | August 2010 | ||||
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| Status: | Not Peer Reviewed | ||||
| Publication Status: | Unpublished | ||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||
| Conference Paper Type: | Lecture | ||||
| Title of Event: | Joint Statistical Meeting | ||||
| Type of Event: | Other | ||||
| Location of Event: | Vancouver, Canada | ||||
| Date(s) of Event: | Jul 31 - Aug 5, 2010 |
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