Nichols, Thomas E., Friston, K. J. (Karl J.), Roiser, Jonathan and Viding, Essi (2010) Dangers of using Falconer’s Heritability estimate with typical imaging genetic sample sizes. In: Poster Session at the 6th International Imaging Genetics Conference, Irvine, CA, U.S.A., Jan 18-19, 2010

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Abstract

Aim of Investigation: Heritability is measured with twins studies, where the correlation of monozygotic (MZ, identical) and dizygotic (DZ, fraternal) twins indicates shared variation due to common environmental and/or genetic influences. The simplest estimate of narrow-sense (additive genetic) heritability is Falconer's estimate (Falconer, 1996). Another estimate comes from a components-of-variance approach, where a structured covariance model expresses the shared genetic and environmental effects (Neale, 1998). This approach has much greater flexibility and can be more powerful (Christian, 1995). While best practice in statistical genetics is to use the components-of-variance/SEM approach, Falconer's method is still widely used in imaging genetics studies. The purpose of this work is to demonstrate the poor performance of Falconer's method and demonstrate the limitations of even the best-practice approch at typical sample sizes.

Item Type:	Conference Item (Poster)
Subjects:	Q Science > QA Mathematics Q Science > QH Natural history > QH426 Genetics
Divisions:	Faculty of Science > Statistics Faculty of Science > WMG (Formerly the Warwick Manufacturing Group)
Library of Congress Subject Headings (LCSH):	Genetics -- Statistical methods, Heredity -- Statistical methods, Sampling (Statistics)
Date:	2010
Status:	Not Peer Reviewed
Publication Status:	Published
Conference Paper Type:	Poster
Title of Event:	Poster Session at the 6th International Imaging Genetics Conference
Type of Event:	Conference
Location of Event:	Irvine, CA, U.S.A.
Date(s) of Event:	Jan 18-19, 2010
URI:	http://wrap.warwick.ac.uk/id/eprint/41170

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