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False positives in imaging genetics using nonstationary cluster-size inference
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Silver, Matt, Nichols, Thomas E. and Montana, Giovanni (2010) False positives in imaging genetics using nonstationary cluster-size inference. In: 17th Annual Meeting of the Organization for Human Brain Mapping, Barcelona, Spain, 10-14 Jun 2010
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Official URL: http://www2.warwick.ac.uk/fac/sci/statistics/staff...
Abstract
Imaging genetic studies present a particular statistical challenge due to the high dimensionality of each domain's data. Specifically some issues have been raised about the adequate control of false positives in imaging genetics. A previous study assessed the effect of a set of 'null' SNPs on brain structure and function. Using voxelwise tests, they found that the empirical familywise error rate (FWE) was at or below 5%, indicating that false positive risk was controlled. Statistical tests based on the size of significant clusters of contiguous voxels are also widely used, due to their typically increased statistical power over voxel-wise tests. With VBM (voxel-based morphometry) data, an adjustment for non-stationarity is made to account for variations in smoothness across the brain. While non-stationary RFT tests have been validated with simulations in small datasets, they have not yet been evaluated with the large datasets typical to imaging genetics.
| Item Type: | Conference Item (Poster) |
|---|---|
| Subjects: | Q Science > QA Mathematics Q Science > QH Natural history > QH426 Genetics R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
| Divisions: | Faculty of Science > Statistics Faculty of Science > WMG (Formerly the Warwick Manufacturing Group) |
| Library of Congress Subject Headings (LCSH): | Genetics -- Statistical methods, Cluster analysis, Probabilities, Brain -- Imaging -- Statistical methods, Brain mapping -- Statistical methods |
| Date: | June 2010 |
| Status: | Not Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Open Access |
| Conference Paper Type: | Poster |
| Title of Event: | 17th Annual Meeting of the Organization for Human Brain Mapping |
| Type of Event: | Other |
| Location of Event: | Barcelona, Spain |
| Date(s) of Event: | 10-14 Jun 2010 |
| URI: | http://wrap.warwick.ac.uk/id/eprint/41174 |
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