The calcium-sensing receptor and insulin secretion : a role outside systemic control 15 years on
Hodgkin, M. N., Hills, Claire E. and Squires, Paul E.. (2008) The calcium-sensing receptor and insulin secretion : a role outside systemic control 15 years on. Journal of Endocrinology, Vol.199 (No.1-4). ISSN 0022-0795
WRAP_Squires_0070376_280109_CaR_2008_revised_pdf.pdf - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Official URL: http://dx.doi.org/10.1677/JOE-08-0261
In the 15 years since the identification and characterisation of the extracellular calcium-sensing receptor (CaR), it has become increasingly apparent that this cationic binding receptor is found in many tissues, not associated with the control of plasma calcium. One of these tissues is the pancreatic islet where insulin secretion provides the basis of energy regulation. It seems inherently unlikely that the islet responds to alterations in systemic calcium and a more plausible and intriguing possibility is that the CaR mediates cell-to-cell communication through local increases in the concentration of extracellular Ca2+, co-released with insulin. This short article explores this possibility and suggests that this novel mechanism of cell communication, along with direct coupling via gap junctions and other local paracrine regulators helps explain why the glucose responsiveness of the intact islet is greater than the sum of the composite parts in isolation.
|Item Type:||Journal Article|
|Subjects:||Q Science > QH Natural history > QH301 Biology|
|Divisions:||Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010)|
|Library of Congress Subject Headings (LCSH):||Insulin, Cell interaction, Calcium -- Receptors|
|Journal or Publication Title:||Journal of Endocrinology|
|Publisher:||Society for Endocrinology|
|Access rights to Published version:||Restricted or Subscription Access|
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