The Library

The calcium-sensing receptor and insulin secretion : a role outside systemic control 15 years on

Tools

Hodgkin, M. N., Hills, Claire E. and Squires, Paul E.. (2008) The calcium-sensing receptor and insulin secretion : a role outside systemic control 15 years on. Journal of Endocrinology, Vol.199 (No.1-4). ISSN 0022-0795

Preview

PDF
WRAP_Squires_0070376_280109_CaR_2008_revised_pdf.pdf - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Download (123Kb)

Official URL: http://dx.doi.org/10.1677/JOE-08-0261

Abstract

In the 15 years since the identification and characterisation of the extracellular calcium-sensing receptor (CaR), it has become increasingly apparent that this cationic binding receptor is found in many tissues, not associated with the control of plasma calcium. One of these tissues is the pancreatic islet where insulin secretion provides the basis of energy regulation. It seems inherently unlikely that the islet responds to alterations in systemic calcium and a more plausible and intriguing possibility is that the CaR mediates cell-to-cell communication through local increases in the concentration of extracellular Ca2+, co-released with insulin. This short article explores this possibility and suggests that this novel mechanism of cell communication, along with direct coupling via gap junctions and other local paracrine regulators helps explain why the glucose responsiveness of the intact islet is greater than the sum of the composite parts in isolation.

Item Type:

Journal Article

Subjects:

Q Science > QH Natural history > QH301 Biology

Divisions:

Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010)

Library of Congress Subject Headings (LCSH):

Insulin, Cell interaction, Calcium -- Receptors

Journal or Publication Title:

Journal of Endocrinology

Publisher:

Society for Endocrinology

ISSN:

0022-0795

Official Date:

2008

Dates:

Date	Event
2008	Published

Volume:

Vol.199

Number:

No.1-4

Identification Number:

10.1677/JOE-08-0261

Status:

Peer Reviewed

Access rights to Published version:

Restricted or Subscription Access

References:

1. Belan P, Gardner J, Gerasimenko O, Gerasimenko J, Mills CL, Petersen OH, Tepikin AV 1998 Isoproterenol evokes extracellular Ca2+ spikes due to secretory events in salivary gland cells. Journal of Biological Chemistry 273 4106-4111.
2. Brown EM, Gamba G, Riccardi D, Lombardi M, Butters R, Kifor O, Sun A, Hedlger MA, Lytton J & Hebert SC 1993 Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid. Nature 366 575-580.
3. Brown EM 2007 The calcium-sensing receptor: physiology, pathophysiology and CaR-based therapeutics. Subcellular Biochemistry 45 139-167.
4. Bruce JIE, Yang X, Ferguson CJ, Elliot AC, Steward MC, Maynard-Case R, Riccardi D 1999 Molecular and functional identification of a Ca2+ (polyvalent cation)-sensing receptor in rat pancreas. Journal of Biological Chemistry 274 20561-20568.
5. Buchan AMJ, Squires PE, Ring M & Meloche MR 2001 Mechanism of action of the calcium-sensing receptor in human antral gastin cells. Gastroenterology 120 1128-1139.
6. Carvell MJ, Marsh PJ, Persaud SJ & Jones PM 2007 E-cadherin interactions regulate β-cell proliferation in islet-like structures. Cellular Physiology and Biochemistry 20 617-626.
7. Cheng SX, Giebel JP & Hebert SC 2004 Extracellular polyamines regulate fluid secretion in rat colonic crypts via the extracellular calcium-sensing receptor. Gastroenterology 126 148-158.
8. D’Souza-Schorey C 2005 Disassembling adherens junctions: breaking up is hard to do. Trends in Cell Biology 15 19-26.
9. Egbuna OI, Brown EM 2008 Hypercalcaemia and hypocalcaemia conditions due to calcium-sensing receptor mutations. Best Practice and Research Clinical Rheumatology 22 129-148.
10. Gray E, Muller D, Squires PE, Asare-Anane H, Huang G-C, Amiel S, Persaud SJ & Jones PM 2006 Activation of the extracellular calcium-sensing receptor initiates
insulin secretion from human islets of Langerhans: involvement of protein kinases. Journal of Endocrinology 190 703-710.
11. Green AK, Stratton RC, Squires PE & Simpson AWM 2007 Atrial natriuretic peptide attenuates elevations in Ca2+ and protects hepatocytes by stimulating net plasma membrane Ca2+ efflux. Journal of Biological Chemistry 282 34542-34554.
12. Hauge-Evans AC, Squires PE, Persaud SJ & Jones PM 1999 Pancreatic β-cell-to-β-cell interactions are required for integrated responses to nutrient stimuli: enhanced Ca2+ and insulin secretory responses of MIN6 pseudoislets. Diabetes 48 1402-1408.
13. Hellman B, Dansk H & Grapengiesser E 2004 Pancreatic β-cells communicate via intermittent release of ATP. American Journal of Physiology 286 E759-E765.
14. Hills CE, Bland R, Wheelans DC, Bennett J, Ronco PM & Squires PE 2006 Glucose-evoked alterations in connexin 43-mediated cell-to-cell communication in human collecting duct: a possible role in diabetic nephropathy. American Journal of Physiology 291 F1045-F1051.
15. Hodgkin MN, Rogers GJ & Squires PE 2007 Co-localization between β-catenin and insulin suggests a novel role for the adherens junction in β-cell function. Pancreas 34 170-171.
16. Hofer AM, Curci S, Doble MA, Brown EM & Soybel DI 2000 Intercellular communication medicated by the extracellular cacium-sensing receptor. Nature Cell Biology 2 392-398.
17. Hofer AM, Gerbino A, Caroppo R & Curci S 2004 The extracellular calcium-sensing receptor and cell-cell signalling in epithelia. Cell Calcium 35 297-306.
18. Ishihara H, Maechler P, Gjinovci A, Herrera P-L & Wollheim CB 2003 Islet β-cell secretion determines glucagons release from neighbouring α-cells. Nature Cell Biology 5 300-335.
19. Jones PM, Kitsou-Mylona I, Gray E, Squires PE & Persaud SJ 2007 Expression and function of the extracellular calcium-sensing receptor in pancreatic β-cells. Archives of Physiology and Biochemistry 113 98-103.
20. Justinich CJ, Mak N, Pacheco I, Mulder D, Wells RW, Blennerhassett MG & MacLeod RJ 2008 The extracellular calcium-sensing receptor (CaSR) on human esophagus and evidence of expression of the CaSR on the esophageal epithelial cell line (HET-1A). American Journal of Physiology 294 G120-G129.
21. Kato M, Doi R, Imamura M, Furutani M, Hosotani R & Shimada Y 1997 Calcium-evoked insulin release from insulinoma cells is mediated via calcium-sensing receptor. Surgery 122 1203-1211.
22. Moreno AP, Berthould V, Perez—Palacios G & Perez-Armendariz EM 2005 Biophysical evidence that connexin-36 forms functional gap junction channels between pancreatic mouse β-cells. American Journal of Physiology 288 E948-E956.
23. Nemeth EF 2004 Calcimimetic and calcilytic drugs: just for parathyroid cells? Cell Calcium 35 283-289.
24. Perez-Armendariz E & Atwater I 1986 Glucose-evoked changes in [K+] and [Ca2+] in the intercellular spaces of the mouse islet of Langerhans. Advances in Experimental Medicine and Biology 211 31-51.
25. Racz GZ, Kittel A, Riccardi D, Case RM, Elliot AC & Varga G 2002 Extracellular calcium sensing receptor in human pancreatic cells. Gut 51 705-711.
26. Rasschaert J & Malaisse WJ 1999 Expression of the calcium-sensing receptor in pancreatic islet β-cells. Biochemical and Biophysical Research Communications 264 615-618.
27. Ray JM, Squires PE, Curtis SB, Meloche MR & Buchan AMJ 1997 Expression of the calcium-sensing receptor on human antral gastrin cells in culture. Journal of Clinical Investigation 99 2328-2333.
28. Rogers GJ, Hodgkin MN & Squires PE 2007 E-cadherin and cell adhesion: a role in architecture and function in the pancreatic islet. Cellular Physiology and Biochemistry 20 987-994.
29. Schlumbohm C & Harmeyer J 2002 Hypocalcemia reduces insulin turnover but not insulin-mediated glucose metabolism in piglets. Acta Diabetologica 39 191-202.
30. Smajilovic S & Tfelt-Hansen J 2007 Calcium acts as a first messenger through the calcium-sensing receptor in the cardiovascular system. Cardiovascular Research 75 457-467.
31. Squires PE, Harris TE, Persaud SJ, Curtis SB, Buchan AMJ, Jones PM 2000 The extracellular calcium-sensing receptor on human β-cells negatively modulates insulin secretion. Diabetes 49 409-417.
32. Squires PE, Persaud SJ, Hauge-Evans AC, Gray E, Ratcliff H & Jones PM 2002 Co-ordinated Ca2+-signalling within pancreatic islets: does β-cell entrainment require a secreted messenger. Cell Calcium 31 209-219.
33. Taylor WH & Khaleeli AA 2001 Coincident diabetes mellitus and primary hyperparathyroidism. Diabetes Metababolism Research and Reviews 17 175-180.
34. Trivedi R, Mithal A & Chattopadhyay N 2008 Recent updates on the calcium-sensing receptor as a drug target. Current Medicinal Chemistry 15 178-186.
35. Tu C-L, Chang W, Xie Z & Bikle DD 2008 Inactivation of the calcium sensing receptor inhibits E-cadherin-mediated cell-cell adhesion and calcium-induced differentiation in human epidermal keratinocytes. Journal of Biological Chemistry 283 3519-3528.
36. Vizard TN, O’Keeffe GW, Gutierrez H, Kos CH, Riccardi D & Davies AM 2008 Regulation of axonal and dendritic growth by the extracellular calcium-sensing receptor. Nature Neuroscience 11 285-291.
37. Won JGS, Tseng H-S, Yang A-H, Yang K-T, Jap T-S, Kwok C-F, Lee CH & Lin H-D 2003 Intra-arterial calcium stimulation test for detection of insulinomas: detection 11
rate, responses of pancreatic peptides, and its relationship to differentiation of tumour cells. Metabolism 52 1320-1329.