The Library
Ionotropic receptors in neuronal–astroglial signalling : what is the role of “excitable” molecules in non-excitable cells
Tools
Lalo, Ulyana, Pankratov, Yuriy, Parpura, Vladimir and Verkhratsky, Alexei (2011) Ionotropic receptors in neuronal–astroglial signalling : what is the role of “excitable” molecules in non-excitable cells. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Volume 1813 (Number 5). pp. 992-1002. doi:10.1016/j.bbamcr.2010.09.007 ISSN 0167-4889.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1016/j.bbamcr.2010.09.007
Abstract
Astroglial cells were long considered to serve merely as the structural and metabolic supporting cast and scenery against which the shining neurones perform their illustrious duties. Relatively recent evidence, however, indicates that astrocytes are intimately involved in many of the brain's functions. Astrocytes possess a diverse assortment of ionotropic transmitter receptors, which enable these glial cells to respond to many of the same signals that act on neurones. Ionotropic receptors mediate neurone-driven signals to astroglial cells in various brain areas including neocortex, hippocampus and cerebellum. Activation of ionotropic receptors trigger rapid signalling events in astroglia; these events, represented by local Ca(2+) or Na(+) signals provide the mechanism for fast neuronal-glial signalling at the synaptic level. Since astrocytes can detect chemical transmitters that are released from neurones and can release their own extracellular signals, gliotransmitters, they are intricately involved in homocellular and heterocellular signalling mechanisms in the nervous system. This article is part of a Special Issue entitled: 11th European Symposium on Calcium. (C) 2010 Elsevier B.V. All rights reserved.
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Subjects: | Q Science > QP Physiology | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
Library of Congress Subject Headings (LCSH): | Cell receptors, Astrocytes, Glutamic acid, Adenosine triphosphate, Methyl aspartate, Purines -- Receptors, Cellular signal transduction, Synapses | ||||
Journal or Publication Title: | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | ||||
Publisher: | Elsevier | ||||
ISSN: | 0167-4889 | ||||
Official Date: | 2011 | ||||
Dates: |
|
||||
Volume: | Volume 1813 | ||||
Number: | Number 5 | ||||
Page Range: | pp. 992-1002 | ||||
DOI: | 10.1016/j.bbamcr.2010.09.007 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Funder: | Alzheimer's Research Trust, National Science Foundation (U.S.) (NSF), Grantová agentura České republiky [Grant Agency of the Czech Republic] (GACR) | ||||
Grant number: | ART/PG2004A/1 (ART), CBET 0943343 (NSF), GACR 305/08/1381 and GACR 305/08/1384 (GACR) |
Data sourced from Thomson Reuters' Web of Knowledge
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |