Osei-Assibey, G., Adi, Y., Kyrou, Ioannis, Kumar, Sudhesh and Matyka, K.. (2011) Pharmacotherapy for overweight/obesity in ethnic minorities and white caucasians : a systematic review and meta-analysis. Diabetes, Obesity and Metabolism, Volume 13 (Number 5). pp. 385-393. ISSN 1462-8902

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Abstract

Ethnic minorities in the West exhibit a higher prevalence of obesity and also under-achieve in weight management compared to White Caucasians. A systematic review of randomized controlled trials (RCTs) in adults (mean age >= 18 years, duration >= 6 months and published in the English language) was undertaken to evaluate the effectiveness of antiobesity drugs in ethnic minorities and White Caucasians. Data sources between 1990 and 2010 were searched including MEDLINE, EMBASE, Cochrane Controlled Trials Register, CINAHL and references cited in the included studies of other reviews. Eighteen RCTs that met the inclusion criteria were included in this review (6 sibutramine and 12 orlistat). A random effects model was used for meta-analysis. An indirect comparison of weight loss in sibutramine-treated patients in ethnic minorities was significantly lower than in White Caucasians: -2.7 kg (95% CI: -3.1 to -2.3) versus -4.4 kg (95% CI: -5.0 to -3.8), respectively. For orlistat, weight loss was similar in the two groups: -2.3 kg (95% CI: -2.6 to -2.0) in ethnic minorities and -2.8 kg (95% CI: -5.1 to -0.5) in White Caucasian participants. Overall, there were few studies of weight loss pharmacotherapy for comparison of this review and it was not possible to analyse data based on ethnic groupings. More ethnically tailored studies are needed to assess the most effective weight loss strategies in these most metabolically vulnerable groups.

Item Type:	Journal Article
Subjects:	R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology
Divisions:	Faculty of Medicine > Warwick Medical School > Clinical Sciences Research Institute (CSRI) Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Appetite depressants, Chemotherapy, Weight loss preparations, Weight loss, Systematic reviews (Medical research), Meta-analysis
Journal or Publication Title:	Diabetes, Obesity and Metabolism
Publisher:	Blackwell
ISSN:	1462-8902
Date:	May 2011
Volume:	Volume 13
Number:	Number 5
Page Range:	pp. 385-393
Identification Number:	10.1111/j.1463-1326.2010.01346.x
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Produits Roche S.A.
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URI:	http://wrap.warwick.ac.uk/id/eprint/41390

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