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Recombinants between Deformed wing virus and Varroa destructor virus-1 may prevail in Varroa destructor-infested honeybee colonies
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Moore, Jonathan D., Jironkin, Aleksey, Chandler, Dave, Burroughs, Nigel John, Evans, David J. and Ryabov, Eugene V. (2011) Recombinants between Deformed wing virus and Varroa destructor virus-1 may prevail in Varroa destructor-infested honeybee colonies. Journal of General Virology, Vol.92 . pp. 156-161. doi:10.1099/vir.0.025965-0 ISSN 0022-1317.
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Official URL: http://dx.doi.org/10.1099/vir.0.025965-0
Abstract
We have used high-throughput Illumina sequencing to identify novel recombinants between
deformed wing virus (DWV) and Varroa destructor virus-1 (VDV-1), which accumulate to
higher levels than DWV in both honeybees and Varroa destructor mites. The recombinants,
VDV-1VVD and VDV-1DVD, exhibit crossovers between the 5’-untranslated region (5’-UTR),
and/or the regions encoding the structural (capsid) and non-structural viral proteins. This
implies the genomes are modular and that each region may evolve independently, as
demonstrated in human enteroviruses. Individual honeybee pupae were infected with a
mixture of observed recombinants and DWV. The strong correlation between VDV-1DVD
levels in honeybee pupae and the associated mites was observed, suggesting that this
recombinant, with a DWV-derived 5’-UTR and non-structural protein region flanking VDV-
1-derived capsid encoding region, is better adapted to transmission between V. destructor and
honeybees than the parental DWV or a recombinant bearing the VDV-1-derived 5’-UTR
(VDV-1VVD).
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QR Microbiology > QR355 Virology | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) Faculty of Science, Engineering and Medicine > Science > Mathematics Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre |
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Library of Congress Subject Headings (LCSH): | Varroa, Picornaviruses, Recombinant viruses, Honeybee -- Diseases | ||||
Journal or Publication Title: | Journal of General Virology | ||||
Publisher: | Society for General Microbiology | ||||
ISSN: | 0022-1317 | ||||
Official Date: | 2011 | ||||
Dates: |
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Volume: | Vol.92 | ||||
Page Range: | pp. 156-161 | ||||
DOI: | 10.1099/vir.0.025965-0 | ||||
Status: | Peer Reviewed | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Great Britain. Dept. for Environment, Food & Rural Affairs (DEFRA), Medical Research Council (Great Britain) (MRC) |
Data sourced from Thomson Reuters' Web of Knowledge
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