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Controlling platinum, ruthenium, and osmium reactivity for anticancer drug design

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Bruijnincx, Pieter C. A. and Sadler, P. J.. (2009) Controlling platinum, ruthenium, and osmium reactivity for anticancer drug design. Advances in Inorganic Chemistry, Vol.61 . pp. 1-62. ISSN 0898-8838

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Official URL: http://dx.doi.org/10.1016/S0898-8838(09)00201-3

Abstract

The main task of the medicinal chemist is to design molecules that interact specifically with derailed or degenerating processes in a diseased organism, translating the available knowledge of pathobiochemical and physiological data into chemically useful information and structures. Current knowledge of the biological and chemical processes underlying diseases is vast and rapidly expanding. In particular the unraveling of the genome in combination with, for instance, the rapid development of structural biology has led to an explosion in available information and identification of new targets for chemotherapy. The task of translating this wealth of data into active and selective new drugs is an enormous, but realistic, challenge. It requires knowledge from many different fields, including molecular biology, chemistry, pharmacology, physiology, and medicine and as such requires a truly interdisciplinary approach. Ultimately, the goal is to design molecules that satisfy all the requirements for a candidate drug to function therapeutically. Therapeutic activity can then be achieved by an understanding of and control over structure and reactivity of the candidate drug through molecular manipulation.

Item Type:	Journal Article
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Divisions:	Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH):	Antineoplastic agents, Platinum -- Therapeutic use, Ruthenium -- Therapeutic use, Osmium -- Therapeutic use
Journal or Publication Title:	Advances in Inorganic Chemistry
Publisher:	Elsevier
ISSN:	0898-8838
Date:	2009
Volume:	Vol.61
Page Range:	pp. 1-62
Identification Number:	10.1016/S0898-8838(09)00201-3
Status:	Peer Reviewed
Access rights to Published version:	Open Access
Funder:	Royal Society (Great Britain), Engineering and Physical Sciences Research Council (EPSRC), Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Nederlandse Organisatie voor Wetenschappelijk Onderzoek [Netherlands Organisation for Scientific Research] (NWO), Wellcome Trust (London, England), European Commission (EC), Scottish Enterprise (SE), Oncosense Ltd.
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URI:	http://wrap.warwick.ac.uk/id/eprint/4143