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Impact of acute hyperglycaemia on endothelial function and retinal vascular reactivity in patients with Type 2 diabetes

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Chittari, Madhu Varma, McTernan, P. G. (Philip G.), Bawazeer, Nahla M., Constantinides, K., Ciotola, M., O'Hare, J. Paul, Kumar, Sudhesh and Ceriello, Antonio. (2011) Impact of acute hyperglycaemia on endothelial function and retinal vascular reactivity in patients with Type 2 diabetes. Diabetic Medicine, Volume 28 (Number 4). pp. 450-454. ISSN 0742-3071

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Official URL: http://dx.doi.org/10.1111/j.1464-5491.2010.03223.x

Abstract

In diabetes, endothelial dysfunction and an altered retinal blood flow have been reported and precede overt macrovascular and microvascular disease. Furthermore, an association between postprandial hyperglycaemia, retinopathy and cardiovascular disease has been observed.

Methods:

Endothelial function and retinal vascular reactivity have been measured in baseline conditions in 10 healthy control subjects and 21 patients with Type 2 diabetes. In the patients with Type 2 diabetes, endothelial function and retinal vascular reactivity have been also measured every hour, for 4 h, during an oral glucose tolerance test. Endothelial function has been evaluated by measuring flow-mediated vasodilation of the brachial artery, while retinal vascular reactivity has been measured using a retinal vessel analyser, during a flicker.

Results:

At 1 and 2 h after glucose ingestion, endothelial function decreased (P < 0.05), while retinal vascular reactivity increased, even at 3 h (P < 0.05), vs. the baseline values.

Conclusion :

Our data highlight that acute hyperglycaemia impacts on endothelial function simultaneously at both macrovascular and at microvascular levels, inducing functional change, which could contribute towards explaining the clinical evidence of a strong association between postprandial hyperglycaemia, cardiovascular disease and retinopathy.

Item Type:

Journal Article

Subjects:

R Medicine > RC Internal medicine

Divisions:

Faculty of Medicine > Warwick Medical School > Translational & Systems Medicine > Metabolic and Vascular Health
Faculty of Medicine > Warwick Medical School

Library of Congress Subject Headings (LCSH):

Hyperglycemia -- Pathophysiology, Vascular endothelium, Non-insulin-dependent diabetes -- Treatment, Retina -- Blood-vessels

Journal or Publication Title:

Diabetic Medicine

Publisher:

Blackwell

ISSN:

0742-3071

Official Date:

April 2011

Dates:

Date	Event
April 2011	Published

Volume:

Volume 28

Number:

Number 4

Page Range:

pp. 450-454

Identification Number:

10.1111/j.1464-5491.2010.03223.x

Status:

Peer Reviewed

Publication Status:

Published

Access rights to Published version:

Restricted or Subscription Access

Funder:

BMI Fellowship

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