Spooner, Robert A. , Smith, Daniel C., Easton, A. J. (Andrew J.), Roberts, Lynne M. and Lord, Mike (J. Mike). (2006) Retrograde transport pathways utilised by viruses and protein toxins. Virology Journal, Vol.3 . p. 26. ISSN 1743-422X

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Abstract

A model has been presented for retrograde transport of certain toxins and viruses from the cell surface to the ER that suggests an obligatory interaction with a glycolipid receptor at the cell surface. Here we review studies on the ER trafficking cholera toxin, Shiga and Shiga-like toxins, Pseudomonas exotoxin A and ricin, and compare the retrograde routes followed by these protein toxins to those of the ER trafficking SV40 and polyoma viruses. We conclude that there is in fact no obligatory requirement for a glycolipid receptor, nor even with a protein receptor in a lipid-rich environment. Emerging data suggests instead that there is no common pathway utilised for retrograde transport by all of these pathogens, the choice of route being determined by the particular receptor utilised.

Item Type:	Journal Article
Subjects:	Q Science > QH Natural history > QH301 Biology
Divisions:	Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010)
Library of Congress Subject Headings (LCSH):	Cells, Pathogenic microorganisms, Glycolipids
Journal or Publication Title:	Virology Journal
Publisher:	BioMed Central Ltd.
ISSN:	1743-422X
Date:	7 April 2006
Volume:	Vol.3
Number of Pages:	10
Page Range:	p. 26
Identification Number:	10.1186/1743-422X-3-26
Status:	Peer Reviewed
Access rights to Published version:	Open Access
Funder:	Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Wellcome Trust (London, England), National Institutes of Health (U.S.) (NIH)
Grant number:	063058/ Z/00/Z (Wellcome), 1U01Al065869 (NIH), QLK 2002 01699 (BBS Research Council)
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URI:	http://wrap.warwick.ac.uk/id/eprint/415

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