The Library
Vitamin D receptor activation and left ventricular hypertrophy in advanced kidney disease
Tools
(2011) Vitamin D receptor activation and left ventricular hypertrophy in advanced kidney disease. American Journal of Nephrology, Volume 33 (Number 2). pp. 139-149. doi:10.1159/000323551 ISSN 0250-8095.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1159/000323551
Abstract
Background: In chronic kidney disease (CKD), left ventricular hypertrophy (LVH) is prevalent and is associated with increased cardiovascular morbidity and mortality. Vitamin D receptor (VDR) activation attenuates LVH progression in animal models. Methods: PRIMO is a multinational, randomized, double-blinded trial with oral paricalcitol in subjects with stages 3-4 CKD, mild-to-moderate LVH and an LV ejection fraction > 50%. The primary endpoint is change in the left ventricular mass index (LVMI) compared with placebo after 48 weeks of treatment. The main secondary endpoints are changes in diastolic function parameters. In this paper, we report baseline characteristics from this study. Results: LVMI was 33.0 +/- 7.5 g/m(2.7) for males and 30.8 +/- 7.2 g/m(2.7) for females (p = 0.04). LVMI correlated with systolic blood pressure (r = 0.24), urine albumin creatinine ratio (r = 0.39), troponin T (r = 0.29), high-sensitivity C-reactive protein (r = 0.25) and plasma levels of B-type brain natriuretic peptide (r = 0.22); all p < 0.01. In multiple linear regression, each remained independently associated with LVMI. The early diastolic velocity of the lateral mitral annulus (E') was 8.1 +/- 2.4 cm/s. E' was inversely correlated with age in univariate (r = -0.14, p = 0.04) and multivariable (p = 0.02) analysis. Conclusion: Among 227 multinational subjects with stages 3-4 CKD, baseline LVMI correlates with baseline blood pressure, urine albumin creatinine ratio and cardiac biomarkers, and baseline diastolic function correlates with age. This research was funded by Abbott Laboratories; ClinicalTrials.gov No. NCT00497146. Copyright (C) 2011 S. Karger AG, Basel
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Subjects: | R Medicine > RC Internal medicine | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
Library of Congress Subject Headings (LCSH): | Kidneys -- Diseases, Heart -- Hypertrophy, Cardiovascular system -- Diseases -- Risk factors, Vitamin D -- Physiological effect | ||||
Journal or Publication Title: | American Journal of Nephrology | ||||
Publisher: | S. Karger AG | ||||
ISSN: | 0250-8095 | ||||
Official Date: | 2011 | ||||
Dates: |
|
||||
Volume: | Volume 33 | ||||
Number: | Number 2 | ||||
Page Range: | pp. 139-149 | ||||
DOI: | 10.1159/000323551 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Funder: | Abbott Laboratories |
Data sourced from Thomson Reuters' Web of Knowledge
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |