Comparative functional genomics of the fission yeasts
. (2011) Comparative functional genomics of the fission yeasts. Science, Vol.332 (No.6032). pp. 930-936. ISSN 0036-8075 Full text not available from this repository.
Official URL: http://dx.doi.org/10.1126/science.1203357
The fission yeast clade-comprising Schizosaccharomyces pombe, S. octosporus, S. cryophilus, and S. japonicus-occupies the basal branch of Ascomycete fungi and is an important model of eukaryote biology. A comparative annotation of these genomes identified a near extinction of transposons and the associated innovation of transposon-free centromeres. Expression analysis established that meiotic genes are subject to antisense transcription during vegetative growth, which suggests a mechanism for their tight regulation. In addition, trans-acting regulators control new genes within the context of expanded functional modules for meiosis and stress response. Differences in gene content and regulation also explain why, unlike the budding yeast of Saccharomycotina, fission yeasts cannot use ethanol as a primary carbon source. These analyses elucidate the genome structure and gene regulation of fission yeast and provide tools for investigation across the Schizosaccharomyces clade.
|Item Type:||Journal Article|
|Divisions:||Faculty of Medicine > Warwick Medical School > Biomedical Cell Biology
Faculty of Medicine > Warwick Medical School
|Journal or Publication Title:||Science|
|Publisher:||American Association for the Advancement of Science|
|Date:||20 May 2011|
|Page Range:||pp. 930-936|
|Access rights to Published version:||Restricted or Subscription Access|
|Funder:||National Human Genome Research Institute (NHGRI), NIH , NHGRI , Clore Fellowship , NSF (USA), NIH , Danish Research Council , Biotechnology and Biological Science Research Council , Stowers Institute , HHMI , National Institute of Child Health and Human Development, NIH , Sloan Foundation , Human Frontier Science Program , Career Award at the Scientific Interface from the Burroughs Wellcome Fund|
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