. (2011) Comparative functional genomics of the fission yeasts. Science, Volume 332 (Number 6032). pp. 930-936. ISSN 0036-8075

Full text not available from this repository.

Abstract

The fission yeast clade-comprising Schizosaccharomyces pombe, S. octosporus, S. cryophilus, and S. japonicus-occupies the basal branch of Ascomycete fungi and is an important model of eukaryote biology. A comparative annotation of these genomes identified a near extinction of transposons and the associated innovation of transposon-free centromeres. Expression analysis established that meiotic genes are subject to antisense transcription during vegetative growth, which suggests a mechanism for their tight regulation. In addition, trans-acting regulators control new genes within the context of expanded functional modules for meiosis and stress response. Differences in gene content and regulation also explain why, unlike the budding yeast of Saccharomycotina, fission yeasts cannot use ethanol as a primary carbon source. These analyses elucidate the genome structure and gene regulation of fission yeast and provide tools for investigation across the Schizosaccharomyces clade.

Item Type:	Journal Article
Subjects:	Q Science > QH Natural history > QH426 Genetics Q Science > QK Botany
Divisions:	Faculty of Medicine > Warwick Medical School > Biomedical Cell Biology Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Fission (Biology), Functional genomics, Schizosaccharomyces
Journal or Publication Title:	Science
Publisher:	American Association for the Advancement of Science
ISSN:	0036-8075
Date:	20 May 2011
Volume:	Volume 332
Number:	Number 6032
Page Range:	pp. 930-936
Identification Number:	10.1126/science.1203357
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	National Institutes of Health (U.S.) (NIH), National Human Genome Research Institute (U.S.) (NHGRI), Clore Fellowship, National Science Foundation (U.S.) (NSF), Denmark. Forskningsrådene [Danish Research Council], Biotechnology and Biological Science Research Council (Great Britain) (BBSRC) , Stowers Institute for Medical Research, Howard Hughes Medical Institute (HHMI) , National Institute of Child Health and Human Development, NIH , Alfred P. Sloan Foundation, Human frontier science program, Burroughs Wellcome Fund (BWF)
References:	1. S. L. Forsburg, Trends Genet. 15, 340 (1999). 2. V. Wood et al., Nature 415, 871 (2002). 3. C. L. Flores, C. Rodríguez, T. Petit, C. Gancedo, FEMS Microbiol. Rev. 24, 507 (2000). 4. Materials and methods are available as supporting material on Science Online. 5. J. Leonardi, J. A. Box, J. T. Bunch, P. Baumann, Nat. Struct. Mol. Biol. 15, 26 (2008). 6. L. H. Wong, K. H. Choo, Trends Genet. 20, 611 (2004). 7. H. P. Cam, K. Noma, H. Ebina, H. L. Levin, S. I. Grewal, Nature 451, 431 (2008). 8. M. Zaratiegui et al., Nature 469, 112 (2011). 9. C. Casola, D. Hucks, C. Feschotte, Mol. Biol. Evol. 25, 29 (2008). 10. S. I. Grewal, A. J. Klar, Genetics 146, 1221 (1997). 11. N. C. Steiner, K. M. Hahnenberger, L. Clarke, Mol. Cell. Biol. 13, 4578 (1993). 12. K. Ishii et al., Science 321, 1088 (2008). 13. S. I. Grewal, Curr. Opin. Genet. Dev. 20, 134 (2010). 14. T. A. Volpe et al., Science 297, 1833 (2002). 15. D. H. Beach, Nature 305, 682 (1983). 16. R. Egel, Curr. Genet. 8, 205 (1984). 17. S. Vengrova, J. Z. Dalgaard, Genes Dev. 18, 794 (2004). 18. S. Sayrac, S. Vengrova, E. L. Godfrey, J. Z. Dalgaard, PLoS Genet. 7, e1001328 (2011). 19. M. Kelly, J. Burke, M. Smith, A. Klar, D. Beach, EMBO J. 7, 1537 (1988). 20. B. Arcangioli, A. J. Klar, EMBO J. 10, 3025 (1991). 21. G. Singh, A. J. Klar, Genetics 162, 591 (2002). 22. B. T. Wilhelm et al., Nature 453, 1239 (2008). 23. J. Z. Levin et al., Nat. Methods 7, 709 (2010). 24. T. Ni et al., PLoS ONE 5, e15271 (2010). 25. M. F. Lin, I. Jungreis, M. Kellis, Nature Precedings, published online 18 August 2010 (http://hdl.handle.net/ 10101/npre.2010.4784.1). 26. N. F. Käufer, J. Potashkin, Nucleic Acids Res. 28, 3003 (2000). 27. M. Gómez, F. Antequera, EMBO J. 18, 5683 (1999). 28. M. L. Eaton, K. Galani, S. Kang, S. P. Bell, D. M. MacAlpine, Genes Dev. 24, 748 (2010). 29. A. B. Lantermann et al., Nat. Struct. Mol. Biol. 17, 251 (2010). 30. Z. Xu et al., Nature 457, 1033 (2009). 31. M. Zofall et al., Nature 461, 419 (2009). 32. T. Matsuzawa et al., Appl. Microbiol. Biotechnol. 87, 715 (2010). 33. T. Uo, T. Yoshimura, N. Tanaka, K. Takegawa, N. Esaki, J. Bacteriol. 183, 2226 (2001). 34. N. Dutrow et al., Nat. Genet. 40, 977 (2008). 35. M. Yassour et al., Genome Biol. 11, R87 (2010). 36. A. Moldón et al., Nature 455, 997 (2008). 37. N. Averbeck, S. Sunder, N. Sample, J. A. Wise, J. Leatherwood, Mol. Cell 18, 491 (2005). 38. J. L. DeRisi, V. R. Iyer, P. O. Brown, Science 278, 680 (1997). 39. I. Wapinski, A. Pfeffer, N. Friedman, A. Regev, Nature 449, 54 (2007). 40. N. F. Lowndes, C. J. McInerny, A. L. Johnson, P. A. Fantes, L. H. Johnston, Nature 355, 449 (1992). 41. H. Abe, C. Shimoda, Genetics 154, 1497 (2000). 42. J. Piskur, E. Rozpedowska, S. Polakova, A. Merico, C. Compagno, Trends Genet. 22, 183 (2006). 43. M. Kellis, N. Patterson, M. Endrizzi, B. Birren, E. S. Lander, Nature 423, 241 (2003). 44. J. Mata, R. Lyne, G. Burns, J. Bähler, Nat. Genet. 32, 143 (2002).
URI:	http://wrap.warwick.ac.uk/id/eprint/41522

Data sourced from Thomson Reuters' Web of Knowledge

Request changes to a record

Actions (login required)

View Item