The Library
Emerging role of thiamine therapy for prevention and treatment of early-stage diabetic nephropathy
Tools
Tools
Tools
Rabbani, Naila and Thornalley, Paul J. (2011) Emerging role of thiamine therapy for prevention and treatment of early-stage diabetic nephropathy. Diabetes, Obesity and Metabolism, Volume 13 (Number 7). pp. 577-583. doi:10.1111/j.1463-1326.2011.01384.x ISSN 1462-8902.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1111/j.1463-1326.2011.01384.x
Abstract
Thiamine supplementation may prevent and reverse early-stage diabetic nephropathy. This probably occurs by correcting diabetes-linked increased clearance of thiamine, maintaining activity and expression of thiamine pyrophosphate-dependent enzymes that help counter the adverse effects of high glucose concentrations-particularly transketolase. Evidence from experimental and clinical studies suggests that metabolism and clearance of thiamine is disturbed in diabetes leading to tissue-specific thiamine deficiency in the kidney and other sites of development of vascular complications. Thiamine supplementation prevented the development of early-stage nephropathy in diabetic rats and reversed increased urinary albumin excretion in patients with type 2 diabetes and microalbuminuria in two recent clinical trials. The thiamine monophosphate prodrug, Benfotiamine, whilst preventing early-stage development of diabetic nephropathy experimentally, has failed to produce similar clinical effect. The probable explanations for this are discussed. Further definitive trials for prevention of progression of early-stage diabetic nephropathy by thiamine are now required.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > RC Internal medicine R Medicine > RM Therapeutics. Pharmacology |
||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
||||
| Library of Congress Subject Headings (LCSH): | Vitamin B1 -- Therapeutic use, Vitamin therapy, Diabetic nephropathies -- Treatment, Diabetic nephropathies -- Prevention | ||||
| Journal or Publication Title: | Diabetes, Obesity and Metabolism | ||||
| Publisher: | Blackwell | ||||
| ISSN: | 1462-8902 | ||||
| Official Date: | July 2011 | ||||
| Dates: |
|
||||
| Volume: | Volume 13 | ||||
| Number: | Number 7 | ||||
| Page Range: | pp. 577-583 | ||||
| DOI: | 10.1111/j.1463-1326.2011.01384.x | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Diabetes UK |
Data sourced from Thomson Reuters' Web of Knowledge
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
