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Temporal repression of core circadian genes is mediated through EARLY FLOWERING 3 in Arabidopsis
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Dixon, Laura E., Knox, Kirsten, Kozma-Bognar, Laszlo, Southern, Megan M., Pokhilko, Alexandra and Millar, Andrew J.. (2011) Temporal repression of core circadian genes is mediated through EARLY FLOWERING 3 in Arabidopsis. Current Biology, Vol.21 (No.2). pp. 120-125. ISSN 0960-9822
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Official URL: http://dx.doi.org/10.1016/j.cub.2010.12.013
Abstract
The circadian clock provides robust, similar to 24 hr biological rhythms throughout the eukaryotes. The clock gene circuit in plants comprises interlocking transcriptional feedback loops, reviewed in [1], whereby the morning-expressed transcription factors CIRCADIAN CLOCK-ASSOCIATED 1 (CCA1) and LATE ELONGATED HYPOCOTYL (LHY) repress the expression of evening genes, notably TIMING OF CAB EXPRESSION 1 (TOC1). EARLY FLOWERING 3 (ELF3) has been implicated as a repressor of light signaling to the clock [2, 3] and, paradoxically, as an activator of the light-induced genes CCA1 and LHY [4, 5]. We use cca1-11 lhy-21 elf3-4 plants to separate the repressive function of ELF3 from its downstream targets CCA1 and LHY. We further demonstrate that ELF3 associates physically with the promoter of PSEUDO-RESPONSE REGULATOR 9 (PRR9), a repressor of CCA1 and LHY expression, in a time-dependent fashion. The repressive function of ELF3 is thus consistent with indirect activation of LHY and CCA1, in a double-negative connection via a direct ELF3 target, PRR9. This mechanism reconciles the functions of ELF3 in the clock network during the night and points to further effects of ELF3 during the day.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QH Natural history > QH301 Biology |
| Divisions: | Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010) |
| Journal or Publication Title: | Current Biology |
| Publisher: | Cell Press |
| ISSN: | 0960-9822 |
| Date: | 25 January 2011 |
| Volume: | Vol.21 |
| Number: | No.2 |
| Page Range: | pp. 120-125 |
| Identification Number: | 10.1016/j.cub.2010.12.013 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Funder: | Biotechnology and Biological Sciences Research Council (BBSRC) , Hungarian Scientific Research Fund (OTKA), Hungarian Academy of Sciences (HAS), Engineering and Physical Sciences Research Council (EPSRC) |
| Grant number: | BB/E015263/1 (BBSRC), OTKA-73362 (OTKA), BB/D019621/1 (EPSRC) |
| URI: | http://wrap.warwick.ac.uk/id/eprint/41620 |
Data sourced from Thomson Reuters' Web of Knowledge
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