Hypofractionated accelerated radiotherapy with concurrent carboplatin for locally advanced squamous cell carcinoma of the head and neck
Chan, A. K., Sanghera, Paul, Choo, B. A., McConkey, Christopher C., Mehanna, Hisham M., Parmar, Satyesh, Pracy, P., Glaholm, John and Hartley, Andrew. (2011) Hypofractionated accelerated radiotherapy with concurrent carboplatin for locally advanced squamous cell carcinoma of the head and neck. Clinical Oncology, Volume 23 (Number 1). pp. 34-39. ISSN 0936-6555Full text not available from this repository.
Official URL: http://dx.doi.org/10.1016/j.clon.2010.07.015
Aims: Hypofractionated accelerated radiotherapy with concurrent carboplatin utilises both advantages of altered fractionation and synchronous chemotherapy to maximise local control in locally advanced head and neck cancer. Such fractionation schedules are increasingly used in the intensity-modulated radiotherapy era and the aim of this study was to determine the outcome of hypofractionated accelerated radiotherapy with carboplatin.
Materials and methods: One hundred and fifty consecutive patients with squamous cell carcinoma of the larynx, oropharynx, oral cavity and hypopharynx (International Union Against Cancer [IUAC] stage II-IV) treated with 55 Gy in 20 fractions over 25 days with concurrent carboplatin were analysed. Outcome measures were 2 year overall survival, local control and disease-free survival.
Results: The median follow-up in surviving patients was 25 months. IUAC stages: II n = 15; III n = 42; IV n = 93. Two year overall survival for all patients was 74.9% (95% confidence interval 66.0-81.7%). Two year local control was 78.3% (95% confidence interval 69.6-84.8%). Two year disease-free survival was 67.2% (95% confidence interval 58.3-74.7%). There were 135 patients with stage III and IV disease. For these patients, the 2 year overall survival, local control and disease-free survival were 74.3% (95% confidence interval 64.7-81.6%), 79.1% (95% confidence interval 69.8-85.9%) and 67.6% (95% confidence interval 58.0-75.4%), respectively. Prolonged grade 3 and 4 mucositis seen at >= 4 weeks were present in 9 and 0.7%, respectively. Late feeding dysfunction (determined by dependence on a feeding tube at 1 year) was seen in 13% of the surviving patients at 1 year.
Conclusion: Hypofractionated accelerated radiotherapy with concurrent carboplatin achieves a high local control. This regimen should be considered for a radiotherapy dose-escalation study using intensity-modulated radiotherapy. (C) 2010 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
|Item Type:||Journal Article|
|Subjects:||R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)|
|Divisions:||Faculty of Medicine > Warwick Medical School|
|Library of Congress Subject Headings (LCSH):||Squamous cell carcinoma, Head -- Cancer -- Radiotherapy, Neck -- Cancer -- Radiotherapy, Antineoplastic agents|
|Journal or Publication Title:||Clinical Oncology|
|Publisher:||Elsevier Science London|
|Official Date:||February 2011|
|Page Range:||pp. 34-39|
|Access rights to Published version:||Restricted or Subscription Access|
|Funder:||Roche, Schering-Plough International|
 Pignon J, Bourhis J, Domenge C, Designe L. Chemotherapy
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