Terzidou, V., Blanks, Andrew M., Kim, S. H., Thornton, Steve and Bennett, P. R.. (2011) Labor and inflammation increase the expression of oxytocin receptor in human amnion. Biology of Reproduction, Vol.84 (No.3). pp. 546-552. ISSN 0006-3363

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Abstract

The oxytocin/oxytocin receptor (OXT/OXTR) system plays an important role in the regulation of parturition. The amnion is a major source of prostaglandins and inflammatory cytokine synthesis, which increase both before and during labor. Amnion is a noncontractile tissue; therefore, the role played by OXT/OXTR in this tissue will be fundamentally different from the role played in myometrial contractions. In the present study, we demonstrate increased OXTR mRNA and protein concentrations in human amnion epithelial cells associated with the onset of labor. We show that incubation of primary human amnion epithelial cells with IL1B results in a rapid, transient up-regulation of OXTR mRNA expression, which peaks in prelabor samples after 6 h. Incubation of prelabor amnion epithelial cells with OXT results in a marked increase of prostaglandin E(2) synthesis, and we demonstrate that OXT activates the extracellular signal-regulated protein kinase signal transduction pathway to stimulate up-regulation of cyclo-oxygenase 2 in human amnion epithelial cells. The increased ability of human amnion to produce prostaglandins in response to OXT treatment suggests a complementary role for the OXT/OXTR system in the activation of human amnion and the onset of labor.

Item Type:	Journal Article
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Medicine > Warwick Medical School > Clinical Sciences Research Institute (CSRI) Faculty of Medicine > Warwick Medical School > Reproductive Health Faculty of Medicine > Warwick Medical School
Journal or Publication Title:	Biology of Reproduction
Publisher:	Society for the Study of Reproduction
ISSN:	0006-3363
Date:	March 2011
Volume:	Vol.84
Number:	No.3
Page Range:	pp. 546-552
Identification Number:	10.1095/biolreprod.110.086785
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Action Medical Research Project , National Institute for Health, Biomedical Research Centre
Grant number:	SP4454 (Action Medical Research Project), DSRR_NG0122/2009 (NIH)
URI:	http://wrap.warwick.ac.uk/id/eprint/41633

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