The Library
A new hypothesis on the mechanism of digital clubbing secondary to pulmonary pathologies
Tools
Toovey, Oliver T. R. and Eisenhauer, Helen J. (2010) A new hypothesis on the mechanism of digital clubbing secondary to pulmonary pathologies. Medical Hypotheses, Volume 75 (Number 6). pp. 511-513. doi:10.1016/j.mehy.2010.07.009 ISSN 0306-9877.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1016/j.mehy.2010.07.009
Abstract
Our hypothesis concerns the chronic activation of macrophages, and the continual production of pro-fibrotic tissue repair factors, as a cause of digital clubbing in an array of pulmonary pathologies. The level of macrophage activation will differ between individuals, corresponding to the variable immune response to these pulmonary pathologies. Due to this variability, there is a corresponding inconsistency in the presentation of clubbing. Although testing of this hypothesis would be difficult, there is evidence to support our theory; including a link to chronic diseases involving granulomas, where there would be a large collection of macrophages present and pathologies in organs with large resident macrophage populations. This theory, therefore, could also be developed to include non-pulmonary causes of clubbing. (C) 2010 Elsevier Ltd. All rights reserved.
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Subjects: | R Medicine > RC Internal medicine | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
Library of Congress Subject Headings (LCSH): | Lungs -- Diseases, Lungs -- Pathophysiology, Symptoms, Macrophages -- Activation | ||||
Journal or Publication Title: | Medical Hypotheses | ||||
Publisher: | Elsevier | ||||
ISSN: | 0306-9877 | ||||
Official Date: | 2010 | ||||
Dates: |
|
||||
Volume: | Volume 75 | ||||
Number: | Number 6 | ||||
Page Range: | pp. 511-513 | ||||
DOI: | 10.1016/j.mehy.2010.07.009 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |