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Fetal fibronectin as a predictor of spontaneous preterm birth : a European perspective

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Chandiramani, Manju, Di Renzo, G. C. (Gian Carlo), Gottschalk, Elisabeth, Helmer, Hanns, Henrich, W. (Wolfgang), Hoesli, Irene, Mol, Ben, Norman, Jane E., Robson, Stephen (Professor), Thornton, Steven and Shennan, A. (Andrew) (2011) Fetal fibronectin as a predictor of spontaneous preterm birth : a European perspective. Journal of Maternal-Fetal and Neonatal Medicine, Volume 24 (Number 2). pp. 330-336. doi:10.3109/14767058.2010.496879

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Official URL: http://dx.doi.org/10.3109/14767058.2010.496879

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Abstract

Preterm birth (PTB) is estimated to account for 6-10% of all births worldwide with 13 million PTBs occurring annually and 1 million resulting in death. The diagnosis of spontaneous preterm labor and accurate prediction of preterm delivery is notoriously difficult. Identification of effective risk assessment markers can potentially improve outcomes by enabling targeted therapy while allowing efficient use of resources and avoiding unnecessary interventions. Advances in perinatal medicine have not reduced PTB and effective measures that improve outcome are yet to be established. However, considerable progress has been made in the development of accurate methods (fetal fibronectin and cervical length assessment) to predict PTB in both symptomatic and asymptomatic high-risk women. The excellent negative predictive value of fFN has the ability to facilitate decision-making regarding admission, in utero transfer, administration of antenatal corticosteroids and/or tocolysis and has been shown to be cost-effective. This review describes the European perspective on the use of fFN and describes ongoing European clinical studies, which are appropriately designed with meaningful endpoints, which will undoubtedly facilitate a better understanding of test accuracy and cost-effectiveness within different populations

Item Type: Journal Article
Subjects: Q Science > QP Physiology
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Fibronectins, Premature labor -- Risk assessment -- Europe, Premature labor -- Prevention -- Europe, Medical care -- Cost effectiveness -- Europe
Journal or Publication Title: Journal of Maternal-Fetal and Neonatal Medicine
Publisher: Informa Healthcare
ISSN: 1476-7058
Official Date: 2011
Dates:
DateEvent
2011Published
Volume: Volume 24
Number: Number 2
Page Range: pp. 330-336
DOI: 10.3109/14767058.2010.496879
Status: Peer Reviewed
Publication Status: Published

Data sourced from Thomson Reuters' Web of Knowledge

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