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Fetal fibronectin as a predictor of spontaneous preterm birth : a European perspective
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Chandiramani, Manju, Di Renzo, G. C. (Gian Carlo), Gottschalk, Elisabeth, Helmer, Hanns, Henrich, W. (Wolfgang), Hoesli, Irene, Mol, Ben, Norman, Jane E., Robson, Stephen (Professor), Thornton, Steven and Shennan, A. (Andrew) (2011) Fetal fibronectin as a predictor of spontaneous preterm birth : a European perspective. Journal of Maternal-Fetal and Neonatal Medicine, Volume 24 (Number 2). pp. 330-336. doi:10.3109/14767058.2010.496879
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Official URL: http://dx.doi.org/10.3109/14767058.2010.496879
Abstract
Preterm birth (PTB) is estimated to account for 6-10% of all births worldwide with 13 million PTBs occurring annually and 1 million resulting in death. The diagnosis of spontaneous preterm labor and accurate prediction of preterm delivery is notoriously difficult. Identification of effective risk assessment markers can potentially improve outcomes by enabling targeted therapy while allowing efficient use of resources and avoiding unnecessary interventions. Advances in perinatal medicine have not reduced PTB and effective measures that improve outcome are yet to be established. However, considerable progress has been made in the development of accurate methods (fetal fibronectin and cervical length assessment) to predict PTB in both symptomatic and asymptomatic high-risk women. The excellent negative predictive value of fFN has the ability to facilitate decision-making regarding admission, in utero transfer, administration of antenatal corticosteroids and/or tocolysis and has been shown to be cost-effective. This review describes the European perspective on the use of fFN and describes ongoing European clinical studies, which are appropriately designed with meaningful endpoints, which will undoubtedly facilitate a better understanding of test accuracy and cost-effectiveness within different populations
| Item Type: | Journal Article | ||||
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| Subjects: | Q Science > QP Physiology R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
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| Divisions: | Faculty of Medicine > Warwick Medical School | ||||
| Library of Congress Subject Headings (LCSH): | Fibronectins, Premature labor -- Risk assessment -- Europe, Premature labor -- Prevention -- Europe, Medical care -- Cost effectiveness -- Europe | ||||
| Journal or Publication Title: | Journal of Maternal-Fetal and Neonatal Medicine | ||||
| Publisher: | Informa Healthcare | ||||
| ISSN: | 1476-7058 | ||||
| Official Date: | 2011 | ||||
| Dates: |
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| Volume: | Volume 24 | ||||
| Number: | Number 2 | ||||
| Page Range: | pp. 330-336 | ||||
| DOI: | 10.3109/14767058.2010.496879 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
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