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New vitamin D analogs and changing therapeutic paradigms
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Cunningham, John and Zehnder, Daniel. (2011) New vitamin D analogs and changing therapeutic paradigms. Kidney International, Volume 79 (Number 7). pp. 702-707. ISSN 0085-2538
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Official URL: http://dx.doi.org/10.1038/ki.2010.387
Abstract
Vitamin D compounds have been used successfully to treat secondary hyperparathyroidism for almost three decades. Side effects of increased levels of serum calcium and phosphate and potential complications have increasingly been recognized as problematic, and this has become an even more difficult clinical challenge with the desire to capitalize on some of the pleiotropic effects of vitamin D. Nonclassical nuclear vitamin D receptor (VDR) effects on the cardiovascular system, kidneys, and immune system, with the prospect of improved patient survival, have moved to center stage. Selective vitamin D compounds with minimal effects on mineral metabolism and with maximal cardiovascular and renal benefits are now needed. New vitamin D compounds already in clinical use, which have an improved side-effect profile and differential nonclassical effects compared with calcitriol, are limited to the three licensed pharmaceuticals-paricalcitol, 22-oxacalcitriol, and doxercalciferol. Other compounds are under early development and it is anticipated that these novel therapeutic concepts will result in new vitamin D therapies that will help to reduce the high mortality rate patients with kidney disease experience. Kidney International (2011) 79, 702-707; doi: 10.1038/ki.2010.387; published online 20 October 2010
| Item Type: | Journal Article | ||||
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| Subjects: | R Medicine > RC Internal medicine R Medicine > RM Therapeutics. Pharmacology |
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| Divisions: | Faculty of Medicine > Warwick Medical School | ||||
| Library of Congress Subject Headings (LCSH): | Vitamin D -- Derivatives -- Therapeutic use, Cardiovascular system -- Diseases -- Treatment, Kidneys -- Diseases -- Treatment, Hyperparathyroidism -- Treatment | ||||
| Journal or Publication Title: | Kidney International | ||||
| Publisher: | Nature Publishing Group | ||||
| ISSN: | 0085-2538 | ||||
| Official Date: | April 2011 | ||||
| Dates: |
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| Volume: | Volume 79 | ||||
| Number: | Number 7 | ||||
| Page Range: | pp. 702-707 | ||||
| Identifier: | 10.1038/ki.2010.387 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Amgen Inc., Abbott | ||||
| URI: | http://wrap.warwick.ac.uk/id/eprint/41728 |
Data sourced from Thomson Reuters' Web of Knowledge
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