Arasaradnam, Ramesh P., Ouaret, N., Joseph, M., Nwokolo, Chuka U., Wedlake, L., Andreyev, J., Bardhan, Karna Dev and Covington, James A., 1973- (2011) Radiation-induced gut damage : identifying 'at risk' patients with an 'electronic nose' (E-NOSE). In: Annual Meeting of British Society of Gasenterology, Birmingham, England, 14-17 Mar 2011. Published in: Gut, Vol.60 (Supp.1). A108-A109.

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Abstract

Introduction Almost all patients undergoing radical pelvic radiotherapy develop bowel symptoms during treatment and half go on to develop chronic bowel symptoms. Acute histological damage, due to the radiation, is at its worst at 2 weeks and then improves; subsequent chronic damage then is sustained over many years. We investigated if changes in gastrointestinal symptoms during radiotherapy correlated with alterations in colonic microbial balance, reflected by changes in the gases released when undigested fibre is fermented. Two hypotheses were investigated in this pilot study: (1) Irradiation alter the microbial flora, reflected by changes in the fermentation profile. (2) An individual's susceptibility to damage may be recognised by their ‘fermentation signature'.

Item Type:	Conference Item (Paper)
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Science > Engineering
Journal or Publication Title:	Gut
Publisher:	B M J Group
ISSN:	0017-5749
Date:	April 2011
Volume:	Vol.60
Number:	Supp.1
Page Range:	A108-A109
Identification Number:	10.1136/gut.2011.239301.227
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Conference Paper Type:	Paper
Title of Event:	Annual Meeting of British Society of Gasenterology
Type of Event:	Other
Location of Event:	Birmingham, England
Date(s) of Event:	14-17 Mar 2011
URI:	http://wrap.warwick.ac.uk/id/eprint/41742

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