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Development, synthesis and characterization of porous biomaterial scaffolds for tissue engineering
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Mallick, Kajal (2009) Development, synthesis and characterization of porous biomaterial scaffolds for tissue engineering. In: Materials Science and Technology Conference and Exhibition (MS&T 08), Pittsburgh, PA, U.S.A., Oct 05-09 2008. Published in: Ceramic Transactions, Vol.206 pp. 115-128. doi:10.1002/9780470538357.ch11 ISSN 1042-1122.
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Official URL: http://dx.doi.org/10.1002/9780470538357.ch11
Abstract
This paper describes recent progress towards the development of freeze casting techniques using variation of camphene (CFC) and water and glycerol (WGFC) to fabricate highly porous network structures of Bioglass, hydroxyapatite (HAP), tricalcium phosphates (TCP), as well as their composites for applications in bone tissue engineering. Solid loading of 10 to 60% of ball milled ceramic slurries were freeze cast followed by sublimation at -70 to 60 degrees C. The green bodies equilibrated at room temperature were then sintered in air to a maximum temperature of 1100 degrees C for 4h, which produced excellent defect free and three-dimensionally interconnected structures with open micro and macropores. The nature of the pore channels varied from dendritic to lamellar geometry with a maximum size of similar to 100 mu m and the uniform strut thickness varying from 1-8 mu m. The porosity of the bioscaffolds increased monotonically from 10 to 70% with the decrease in loading volume. Microstructural analysis of porous structures was used to extract information on geometry, porosity and pore size distribution. DTA-TGA, SEM, XRD and density were used to characterize precursor powders, slurry and sintered products. The study proved particularly useful to assess the suitability of the 3-D structures produced by these methods for tissue engineering applications.
Item Type: | Conference Item (Paper) | ||||
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Subjects: | T Technology > TA Engineering (General). Civil engineering (General) | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering Faculty of Science, Engineering and Medicine > Engineering > WMG (Formerly the Warwick Manufacturing Group) |
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Journal or Publication Title: | Ceramic Transactions | ||||
Publisher: | John Wiley & Sons, Inc. | ||||
ISSN: | 1042-1122 | ||||
Book Title: | Advances in Biomedical and Biomimetic Materials | ||||
Official Date: | 2009 | ||||
Dates: |
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Volume: | Vol.206 | ||||
Page Range: | pp. 115-128 | ||||
DOI: | 10.1002/9780470538357.ch11 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Version or Related Resource: | This item was also presented as a chapter in Advances in biomedical and biomimetic materials: a collection of papers presented at the 2008 Materials science and technology conference, edited by R.J. Narayan, , P.N. Kumpta, and W.R. Wagner, and published by the American Ceramic Society, Hoboken, NJ, U.S.A. ISBN: 9780470408476, pp. 115 - 128. | ||||
Conference Paper Type: | Paper | ||||
Title of Event: | Materials Science and Technology Conference and Exhibition (MS&T 08) | ||||
Type of Event: | Conference | ||||
Location of Event: | Pittsburgh, PA, U.S.A. | ||||
Date(s) of Event: | Oct 05-09 2008 |
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