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Ionotropic ATP receptors in neuronal–glial communication
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Lalo, Ulyana, Verkhratsky, Alexei and Pankratov, Yuriy (2011) Ionotropic ATP receptors in neuronal–glial communication. Seminars in Cell and Developmental Biology, Vol.22 (No.2). pp. 220-228. doi:10.1016/j.semcdb.2011.02.012 ISSN 1084-9521.
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Official URL: http://dx.doi.org/10.1016/j.semcdb.2011.02.012
Abstract
In the central nervous system ATP is released from both neurones and astroglial cells acting as a homo-and heterocellular neurotransmitter. Glial cells express numerous purinoceptors of both ionotropic (P2X) and metabotropic (P2Y) varieties. Astroglial P2X receptors can be activated by ongoing synaptic transmission and can mediate fast local signalling through elevation in cytoplasmic Ca(2+) and Na(+) concentrations. These ionic signals can be translated into various physiological messages by numerous pathways, including release of gliotransmitters, metabolic support of neurones and regulation of activity of postsynaptic glutamate and GABA receptors. Ionotropic purinoceptors represent a novel pathway of glia-driven modulation of synaptic signalling that involves the release of ATP from neurones and astrocytes followed by activation of P2X receptors which can regulate synaptic activity by variety of mechanisms expressed in both neuronal and glial compartments. (C) 2011 Elsevier Ltd. All rights reserved.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
| Journal or Publication Title: | Seminars in Cell and Developmental Biology | ||||
| Publisher: | Elsevier Science Ltd. / Academic Press Ltd. | ||||
| ISSN: | 1084-9521 | ||||
| Official Date: | April 2011 | ||||
| Dates: |
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| Volume: | Vol.22 | ||||
| Number: | No.2 | ||||
| Page Range: | pp. 220-228 | ||||
| DOI: | 10.1016/j.semcdb.2011.02.012 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Biotechnology and Biological Sciences Research Council (BBSRC) | ||||
| Grant number: | BB/F0221445 (BBSRC) |
Data sourced from Thomson Reuters' Web of Knowledge
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