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Purinergic signaling in hypothalamic tanycytes : potential roles in chemosensing
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Dale, Nicholas. (2011) Purinergic signaling in hypothalamic tanycytes : potential roles in chemosensing. Seminars in Cell and Developmental Biology, Vol.22 (No.2). pp. 237-244. ISSN 1084-9521
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Official URL: http://dx.doi.org/10.1016/j.semcdb.2011.02.024
Abstract
Hypothalamic tanycytes are cells that line the walls of the 3rd ventricle. Their cell bodies contact the cerebrospinal fluid and give rise to an inwardly directed process. The more dorsally located (alpha 1 and alpha 2) tanycytes project to areas of the brain involved in the control of feeding and energy balance (the arcuate nucleus and ventromedial hypothalamic nucleus). Although their functions are poorly understood, they have some similarities to glial cells. Recent evidence shows that they express key molecules involved in purinergic signaling and at least some tanycytes may act as adult multipotent stem cells. Emerging evidence suggests that tanycytes signal through changes in intracellular Ca(2+) and that they can respond with large Ca(2+) signals to ATP and transmitters associated with wakefulness and the drive to feed. They are also glucosensitive and this response is dependent on release of ATP from tanycytes and the activation of P2Y1 receptors. Their ability to release ATP gives potential for their integration into the hypothalamic circuitry controlling energy balance and feeding, but many fundamental questions about their possible functions and roles remain unanswered. (C) 2011 Elsevier Ltd. All rights reserved.
| Item Type: | Journal Article |
|---|---|
| Divisions: | Faculty of Science > Life Sciences (2010- ) |
| Journal or Publication Title: | Seminars in Cell and Developmental Biology |
| Publisher: | Elsevier Science Ltd. / Academic Press Ltd. |
| ISSN: | 1084-9521 |
| Date: | April 2011 |
| Volume: | Vol.22 |
| Number: | No.2 |
| Page Range: | pp. 237-244 |
| Identification Number: | 10.1016/j.semcdb.2011.02.024 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| Funder: | Medical Research Council (MRC) |
| URI: | http://wrap.warwick.ac.uk/id/eprint/41808 |
Data sourced from Thomson Reuters' Web of Knowledge
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