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Ringing the changes: emerging roles for DASH at the kinetochore–microtubule Interface
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Buttrick, Graham J. and Millar, Jonathan B. A. (2011) Ringing the changes: emerging roles for DASH at the kinetochore–microtubule Interface. Chromosome Research, Vol.19 (No.3). pp. 393-407. doi:10.1007/s10577-011-9185-8 ISSN 0967-3849.
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Official URL: http://dx.doi.org/10.1007/s10577-011-9185-8
Abstract
Regulated interaction between kinetochores and the mitotic spindle is essential for the fidelity of chromosome segregation. Potentially deleterious attachments are corrected during prometaphase and metaphase. Correct attachments must persist during anaphase, when spindle-generated forces separate chromosomes to opposite poles. In yeast, the heterodecameric DASH complex plays a vital pole in maintaining this link. In vitro DASH forms both oligomeric patches and rings that can form load-bearing attachments with the tips of polymerising and depolymerising microtubules. In vivo, DASH localises primarily at the kinetochore, and has a role maintaining correct attachment between spindles and chromosomes in both Saccharomyces cerevisiae and Schizosaccharomyces pombe. Recent work has begun to describe how DASH acts alongside other components of the outer kinetochore to create a dynamic, regulated kinetochore-microtubule interface. Here, we review some of the key experiments into DASH function and discuss their implications for the nature of kinetochore-microtubule attachments in yeast and other organisms.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Chromosome Research | ||||
| Publisher: | Springer | ||||
| ISSN: | 0967-3849 | ||||
| Official Date: | 2011 | ||||
| Dates: |
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| Volume: | Vol.19 | ||||
| Number: | No.3 | ||||
| Page Range: | pp. 393-407 | ||||
| DOI: | 10.1007/s10577-011-9185-8 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
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