Springs, clutches and motors : driving forward kinetochore mechanism by modelling
Vladimirou, Elina, Harry, Ed, Burroughs, Nigel John and McAinsh, Andrew D.. (2011) Springs, clutches and motors : driving forward kinetochore mechanism by modelling. Chromosome Research, Vol.19 (No.3). pp. 409-421. ISSN 0967-3849Full text not available from this repository.
Official URL: http://dx.doi.org/10.1007/s10577-011-9191-x
As a mechanical system, the kinetochore can be viewed as a set of interacting springs, clutches and motors; the problem of kinetochore mechanism is now one of understanding how these functional modules assemble, disassemble and interact with one another to give rise to the emergent properties of the system. The sheer complexity of the kinetochore system points to a future requirement for data-driven mathematical modelling and statistical analysis based on quantitative empirical measurement of sister kinetochore trajectories. Here, we review existing models of chromosome motion in the context of recent advances in our understanding of kinetochore molecular biology.
|Item Type:||Journal Article|
|Divisions:||Faculty of Medicine > Warwick Medical School > Biomedical Cell Biology
Faculty of Science > Centre for Systems Biology
Faculty of Medicine > Warwick Medical School
|Journal or Publication Title:||Chromosome Research|
|Page Range:||pp. 409-421|
|Access rights to Published version:||Restricted or Subscription Access|
|Funder:||Engineering and Physical Sciences Research Council (EPSRC) , Marie Curie Cancer Care|
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