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Springs, clutches and motors : driving forward kinetochore mechanism by modelling
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Vladimirou, Elina, Harry, Edward, Burroughs, Nigel John and McAinsh, Andrew D. (2011) Springs, clutches and motors : driving forward kinetochore mechanism by modelling. Chromosome Research, Volume 19 (Number 3). pp. 409-421. doi:10.1007/s10577-011-9191-x
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Official URL: http://dx.doi.org/10.1007/s10577-011-9191-x
Abstract
As a mechanical system, the kinetochore can be viewed as a set of interacting springs, clutches and motors; the problem of kinetochore mechanism is now one of understanding how these functional modules assemble, disassemble and interact with one another to give rise to the emergent properties of the system. The sheer complexity of the kinetochore system points to a future requirement for data-driven mathematical modelling and statistical analysis based on quantitative empirical measurement of sister kinetochore trajectories. Here, we review existing models of chromosome motion in the context of recent advances in our understanding of kinetochore molecular biology.
| Item Type: | Journal Article | ||||||
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| Subjects: | Q Science > QR Microbiology | ||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Mitosis, Spindle (Cell division) | ||||||
| Journal or Publication Title: | Chromosome Research | ||||||
| Publisher: | Springer | ||||||
| ISSN: | 0967-3849 | ||||||
| Official Date: | April 2011 | ||||||
| Dates: |
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| Volume: | Volume 19 | ||||||
| Number: | Number 3 | ||||||
| Number of Pages: | 13 | ||||||
| Page Range: | pp. 409-421 | ||||||
| DOI: | 10.1007/s10577-011-9191-x | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access | ||||||
| Funder: | Engineering and Physical Sciences Research Council (EPSRC) , Marie Curie Cancer Care |
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