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Springs, clutches and motors : driving forward kinetochore mechanism by modelling

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Vladimirou, Elina, Harry, Edward, Burroughs, Nigel John and McAinsh, Andrew D. (2011) Springs, clutches and motors : driving forward kinetochore mechanism by modelling. Chromosome Research, Volume 19 (Number 3). pp. 409-421. doi:10.1007/s10577-011-9191-x

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Official URL: http://dx.doi.org/10.1007/s10577-011-9191-x

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Abstract

As a mechanical system, the kinetochore can be viewed as a set of interacting springs, clutches and motors; the problem of kinetochore mechanism is now one of understanding how these functional modules assemble, disassemble and interact with one another to give rise to the emergent properties of the system. The sheer complexity of the kinetochore system points to a future requirement for data-driven mathematical modelling and statistical analysis based on quantitative empirical measurement of sister kinetochore trajectories. Here, we review existing models of chromosome motion in the context of recent advances in our understanding of kinetochore molecular biology.

Item Type: Journal Article
Subjects: Q Science > QR Microbiology
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology
Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Mitosis, Spindle (Cell division)
Journal or Publication Title: Chromosome Research
Publisher: Springer
ISSN: 0967-3849
Official Date: April 2011
Dates:
DateEvent
April 2011Published
18 February 2011Available
Volume: Volume 19
Number: Number 3
Number of Pages: 13
Page Range: pp. 409-421
DOI: 10.1007/s10577-011-9191-x
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
Funder: Engineering and Physical Sciences Research Council (EPSRC) , Marie Curie Cancer Care

Data sourced from Thomson Reuters' Web of Knowledge

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