Vladimirou, Elina, Harry, Ed, Burroughs, Nigel John and McAinsh, Andrew D.. (2011) Springs, clutches and motors : driving forward kinetochore mechanism by modelling. Chromosome Research, Vol.19 (No.3). pp. 409-421. ISSN 0967-3849

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Abstract

As a mechanical system, the kinetochore can be viewed as a set of interacting springs, clutches and motors; the problem of kinetochore mechanism is now one of understanding how these functional modules assemble, disassemble and interact with one another to give rise to the emergent properties of the system. The sheer complexity of the kinetochore system points to a future requirement for data-driven mathematical modelling and statistical analysis based on quantitative empirical measurement of sister kinetochore trajectories. Here, we review existing models of chromosome motion in the context of recent advances in our understanding of kinetochore molecular biology.

Item Type:	Journal Article
Divisions:	Faculty of Medicine > Warwick Medical School > Biomedical Cell Biology Faculty of Science > Centre for Systems Biology Faculty of Medicine > Warwick Medical School
Journal or Publication Title:	Chromosome Research
Publisher:	Springer
ISSN:	0967-3849
Official Date:	April 2011
Volume:	Vol.19
Number:	No.3
Page Range:	pp. 409-421
Identification Number:	10.1007/s10577-011-9191-x
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Engineering and Physical Sciences Research Council (EPSRC) , Marie Curie Cancer Care
URI:	http://wrap.warwick.ac.uk/id/eprint/41815

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