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S49 Is the development of acute lung injury influenced by increased levels of IL17 as a result of Treg/TH17 imbalance?
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Dancer, R. C. A., D'Souza, V., Jeffery, L., Sansom, D., Bassford, Christopher R., Perkins, Gavin D. and Thickett, D. R. (2010) S49 Is the development of acute lung injury influenced by increased levels of IL17 as a result of Treg/TH17 imbalance? Thorax, Vol.65 (Suppl. 4). A24-A25. doi:10.1136/thx.2010.150912.49 ISSN 0040-6376.
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Official URL: http://dx.doi.org/10.1136/thx.2010.150912.49
Abstract
Vitamin D is known to have profound effects on the immune system. We have shown that vitamin D is lower in patients with Acute Lung Injury (ALI) than in healthy or at risk controls and that in patients at risk of ALI post oesophagectomy, low vitamin D levels are associated with increased post-operative systemic inflammatory response and alveolar epithelial dysfunction. Studies have shown that when T cells are exposed to vitamin D, expression of IL17 decreases and regulatory capacity increases. We hypothesised that vitamin D deficiency may play a role in development of Acute Lung Injury (ALI) via changes in the balance between regulatory T cells (Treg) and pro-inflammatory Th17 cells.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
Journal or Publication Title: | Thorax | ||||
Publisher: | BMJ | ||||
ISSN: | 0040-6376 | ||||
Official Date: | 2010 | ||||
Dates: |
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Volume: | Vol.65 | ||||
Number: | Suppl. 4 | ||||
Page Range: | A24-A25 | ||||
DOI: | 10.1136/thx.2010.150912.49 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
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