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Lifetime body mass index, other anthropometric measures of obesity and risk of knee or hip osteoarthritis in the GOAL case-control study
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Holliday, K. L., McWilliams, D. F., Maciewicz, Rose A., Muir, Kenneth, Zhang, Weiya and Doherty, Michael (2011) Lifetime body mass index, other anthropometric measures of obesity and risk of knee or hip osteoarthritis in the GOAL case-control study. Osteoarthritis and Cartilage, Vol.19 (No.1). pp. 37-43. doi:10.1016/j.joca.2010.10.014 ISSN 1063-4584.
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Official URL: http://dx.doi.org/10.1016/j.joca.2010.10.014
Abstract
Objective: To examine the risk of large joint osteoarthritis (OA) in those becoming overweight during early adult life, and to assess the risks associated with high body mass index (BMI) and other anthropometric measures of obesity.
Methods: BMI, waist and hip circumference were measured in the GOAL case-control study comprising hip OA cases (n = 1007), knee OA cases (n = 1042) and asymptomatic controls (n = 1121). Retrospective estimates of lifetime weight, body shape and other risk factors were collected using an interview-lead questionnaire. Odds ratios (ORs), adjusted OR (aOR), 95% confidence intervals (Os) and P values were calculated using logistic regression analysis.
Results: BMI was associated with knee OA (aOR 2.68, 95% CI 2.33-3.09, P-trend <0.001) and hip OA (aOR 1.65, 95% CI 1.46-1.87, P-trend <0.001). Those who became overweight earlier in adulthood showed higher risks of lower limb OA (P-trend < 0.001 for knee OA and hip OA). Self-reported body shape was also associated with knee OA and hip OA, following a similar pattern to current and life-course BMI measures. Waist:hip ratio (WHR) at time of examination did not associate with OA independently of BMI, except in women-only analysis. Waist circumference was associated with lower limb OA risk.
Conclusions: Becoming overweight earlier in adult life increased the risks of knee OA and hip OA. Different distribution patterns of adiposity may be related to OA risk in women. (C) 2010 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
Journal or Publication Title: | Osteoarthritis and Cartilage | ||||
Publisher: | Elsevier Science BV | ||||
ISSN: | 1063-4584 | ||||
Official Date: | 2011 | ||||
Dates: |
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Volume: | Vol.19 | ||||
Number: | No.1 | ||||
Page Range: | pp. 37-43 | ||||
DOI: | 10.1016/j.joca.2010.10.014 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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