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Pharmacological use of l-carnitine in uremic anemia : has its full potential been exploited?
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Bonomini, Mario, Zammit, Victor A., Pusey, Charles D., De Vecchi, Amedeo and Arduini, Arduino. (2011) Pharmacological use of l-carnitine in uremic anemia : has its full potential been exploited? Pharmacological Research, Vol.63 (No.3). pp. 157-164. ISSN 1043-6618
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Official URL: http://dx.doi.org/10.1016/j.phrs.2010.11.006
Abstract
Anemia is one of the most frequent complications of kidney failure and a common cause of morbidity in dialysis patients. A number of clinical studies have suggested that L-carnitine (LC), a naturally occurring compound involved in bioenergetic processes, may alleviate the anemia of hemodialysis patients. Since LC deficiency is commonly present in dialysis patients, LC has been described as a "conditional vitamin". However, the use of LC supplementation in dialysis remains controversial as well as its mode of action in preventing anemia. Recent literature shows that to fully exploit its pharmacological potential. LC may have to be administered at doses that achieve supra-physiological levels of LC in plasma and target organs. However, this concept has not been fully investigated in uremic patients. In this article, we will review the use of LC in dialysis patients, and provide a rationale for the anti-anemic action of LC based on biophysical, metabolic and antiapoptotic effects of this compound on erythropoiesis and the function of mature, circulating erythrocytes. The discussion will be focused on experimental and clinical data that support the concept that supra-physiological concentrations of LC may improve the anemic condition of dialysis patients, as would be expected from a "conditional drug" rather than a "conditional vitamin". (C) 2010 Elsevier Ltd. All rights reserved.
| Item Type: | Journal Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Warwick Medical School > Clinical Sciences Research Institute (CSRI) Faculty of Medicine > Warwick Medical School |
| Journal or Publication Title: | Pharmacological Research |
| Publisher: | Academic Press |
| ISSN: | 1043-6618 |
| Date: | 2011 |
| Volume: | Vol.63 |
| Number: | No.3 |
| Page Range: | pp. 157-164 |
| Identification Number: | 10.1016/j.phrs.2010.11.006 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| URI: | http://wrap.warwick.ac.uk/id/eprint/41907 |
Data sourced from Thomson Reuters' Web of Knowledge
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