Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Modest amyloid deposition is associated with iron dysregulation, microglial activation, and oxidative stress

Tools
- Tools
+ Tools

Gallagher, Joseph J., Finnegan, Mary E., Grehan, Belinda, Dobson, Jon, Collingwood, Joanna F. and Lynch, Marina A (2012) Modest amyloid deposition is associated with iron dysregulation, microglial activation, and oxidative stress. Journal of Alzheimer's disease : JAD, Vol.28 (No.1). pp. 147-161. doi:10.3233/JAD-2011-110614

Research output not available from this repository, contact author.
Official URL: http://dx.doi.org/10.3233/JAD-2011-110614

Request Changes to record.

Abstract

There is a well-established literature indicating a relationship between iron in brain tissue and Alzheimer's disease (AD). More recently, it has become clear that AD is associated with neuroinflammatory and oxidative changes which probably result from microglial activation. In this study, we investigated the correlative changes in microglial activation, oxidative stress, and iron dysregulation in a mouse model of AD which exhibits early-stage amyloid deposition. Microfocus X-ray absorption spectroscopy analysis of intact brain tissue sections prepared from AβPP/PS1 transgenic mice revealed the presence of magnetite, a mixed-valence iron oxide, and local elevations in iron levels in tissue associated with amyloid-β-containing plaques. The evidence indicates that the expression of markers of microglial activation, CD11b and CD68, and astrocytic activation, GFAP, were increased, and were histochemically determined to be adjacent to amyloid-β-containing plaques. These findings support the contention that, in addition to glial activation and oxidative stress, iron dysregulation is an early event in AD pathology.

Item Type: Journal Article
Subjects: T Technology > TA Engineering (General). Civil engineering (General)
Divisions: Faculty of Science > Engineering
Journal or Publication Title: Journal of Alzheimer's disease : JAD
Publisher: IOS Press
ISSN: 1387-2877
Official Date: 2012
Dates:
DateEvent
2012Published
Volume: Vol.28
Number: No.1
Page Range: pp. 147-161
DOI: 10.3233/JAD-2011-110614
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: Diamond Light Source , Advantage West Midlands (AWM) , European Regional Development Fund (ERDF), Health Research Board (Ireland) , Science Foundation Ireland

Data sourced from Thomson Reuters' Web of Knowledge

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item
twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us